Schönlau et al., Eur J Immunol 2000
(Leishmaniasis) :
CD18 is also involved in reduction of IL-12 release by L. major infected macrophages, as uptake of opsonized parasites ( via CR3 ) decreased IL-12 release only in WT, but not in CD18-/- macrophages
Perera et al., J Immunol 2001
:
In contrast, for optimal induction of COX-2, IL-12 p35, and IL-12 p40 genes by low concentrations of LPS or by all concentrations of Taxol, CD11b/CD18 was also required