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IL12A — JAK1

Text-mined interactions from Literome

Franchimont et al., J Immunol 2000 : This occurred even though the level of expression of IL-12 receptors and IL-12 induced Janus kinase phosphorylation remained unaltered
Walker et al., Arch Virol Suppl 2005 (Ehrlichiosis) : Ehrlichiae attach to L-selectin and E-selectin, inhibit phagolysosomal fusion, apoptosis, and JAK/STAT activation, and downregulate IL-12 , IL-15, IL-18, TLR2 and 3, and CD14
Shaw et al., J Immunol 2006 (Genetic Predisposition to Disease...) : The Jak , Tyk2, is activated in response to IL-12 and IFN-alphabeta and promotes IFN-gamma production by Th1-type CD4 cells
Yu et al., Biochem Pharmacol 2008 : Like quercetin inhibits macrophage induced cytokine production, it also blocks IL-12 dependent JAK-STAT signaling in Th cells
Wang et al., Blood 2008 (MAP Kinase Signaling System) : IL-12 and IL-18 stimulated autoreactively activated NKT cells to secrete IFN-gamma, and this was mediated by Janus kinase-signal transducers and activators of transcription ( JAK-STAT ) -dependent signaling without induction of calcium flux
Conzelmann et al., Biochem Pharmacol 2010 : We demonstrate that IFN-? induced Janus kinase 1 (JAK1) enhances CD40 induced IL-12p70 release whilst simultaneously inhibiting IL-10 synthesis, resulting in a pro-inflammatory phenotype of CD40L activated dendritic cells (DCs) ... The mechanism by which complementary IFN-?/JAK activities affect IL-12p70 production involves STAT1 activation and de novo induction of interferon-responsive factors (IRF)-1 and IRF-8
Bright et al., J Immunol 1998 : TGF-beta inhibits IL-12 induced activation of Jak-STAT pathway in T lymphocytes