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IL12A — SCG2

Text-mined interactions from Literome

Harada et al., J Interferon Cytokine Res 2002 : In addition, interleukin-12 p70 (IL-12p70) was induced by SCG in DBA/2 mice
Harada et al., J Interferon Cytokine Res 2004 : The addition of recombinant murine GM-CSF ( rMuGM-CSF ) to spleen cell cultures from various strains of mice synergistically enhanced IFN-gamma, TNF-alpha and IL-12p70 in the presence of SCG
Harada et al., J Interferon Cytokine Res 2006 : We recently found that the splenocytes from naive DBA/1 and DBA/2 mice are potently induced by SCG to produce interferon- gamma (IFN-gamma), tumor necrosis factor-alpha (TNF-alpha), granulocyte-macrophage colony stimulating factor ( GM-CSF ), and interleukin-12p70 (IL-12p70) , and that GM-CSF plays a key biologic role among these cytokines ... Cell-cell contact involving intercellular adhesion molecule-1 ( ICAM-1 ) and lymphocyte function associated antigen-1 ( LFA-1 ) was an essential step for the induction of GM-CSF and IFN-gamma by SCG but not for the induction of TNF-alpha or IL-12p70 by SCG ... SCG directly induced adherent splenocytes to produce TNF-alpha and IL-12p70
Harada et al., Microbiol Immunol 2006 (Leukopenia) : The levels of interferon-(IFN-)gamma, tumor necrosis factor-(TNF-)alpha, granulocyte-macrophage-colony stimulating factor ( GM-CSF ), interleukin-(IL-) 6 and IL-12p70 were significantly increased by SCG in CY-treated mice ... Neutralizing GM-CSF significantly inhibited the induction of IFN-gamma, TNF-alpha and IL-12p70 by SCG ... Blocking dectin-1 significantly inhibited the induction of TNF-alpha and IL-12p70 production by SCG