◀ Back to IL12A

IL12A — TNFSF10

Text-mined interactions from Literome

Smyth et al., J Exp Med 2001 (Carcinoma, Renal Cell...) : Administration of therapeutic doses of interleukin (IL)-12, a powerful inducer of interferon (IFN)-gamma production by NK cells and NKT cells, upregulated TRAIL expression on liver, spleen, and lung NK cells, and IL-12 suppressed metastases in both liver and lung in a TRAIL dependent fashion
Takeda et al., Hum Cell 2001 (Neoplasm Metastasis...) : Consisting with this finding, IL-12 and NKT cell specific ligand, alpha-Galactosylceramide ( alpha-GalCer ), induced TRAIL mediated cytotoxcity and anti-tumor effect, and which was mediated by TRAIL expressed on IFN-gamma activated NK cells
Zhang et al., Hum Immunol 2008 : Also, IL-12 augmented the expression of cytotoxic effector molecules, TRAIL and perforin, and the phosphorylation of STAT1, STAT4, and ERK1/2, which may also contribute to lysis by NK cells
Chiu et al., J Biomed Sci 2012 (Disease Models, Animal...) : The treatment of glioblastoma multiforme through activation of microglia and TRAIL induced by rAAV2 mediated IL-12 in a syngeneic rat model
Fu et al., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2012 : [IL-12 induced expression of TRAIL enhances the cytotoxicity of NK cells against Jurkat cells ] ... IL-12 induced expression of TRAIL on NK cells mediated the cytotoxicity to Jurkat cells