Gene interactions and pathways from curated databases and text-mining

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HTT — PGC

Text-mined interactions from Literome

Xiang et al., J Neurosci 2011 (Demyelinating Diseases...) : Importantly, expression of mutant huntingtin (Htt) in primary oligodendrocytes resulted in decreased expression of PGC1a and its targets HmgcS1, Hmgcr, and MBP
Puddifoot et al., J Neurosci 2012 (Disease Models, Animal...) : Here we show that PGC-1a controls NMDAR ( EX ) activity in neurons and that its suppression contributes to mutant Huntingtin ( mHtt ) -induced increases in NMDAR ( EX ) activity and vulnerability to excitotoxic insults