Xiang et al., J Neurosci 2011
(Demyelinating Diseases...) :
Importantly, expression of mutant huntingtin (Htt) in primary oligodendrocytes resulted in decreased expression of PGC1a and its targets HmgcS1, Hmgcr, and MBP
Puddifoot et al., J Neurosci 2012
(Disease Models, Animal...) :
Here we show that PGC-1a controls NMDAR ( EX ) activity in neurons and that its suppression contributes to mutant Huntingtin ( mHtt ) -induced increases in NMDAR ( EX ) activity and vulnerability to excitotoxic insults