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PPP2CA — SHC1

Text-mined interactions from Literome

Ugi et al., Mol Cell Biol 2002 : We conclude ( i ) that PP2A negatively regulates the Ras/MAP kinase pathway by binding to Shc , inhibiting tyrosine phosphorylation ; ( ii ) that the Shc-PP2A association is mediated by the Shc PTB domain but the interaction is independent of phosphotyrosine binding, indicating a new molecular function for the PTB domain ; ( iii ) that growth factor stimulation, or small-t-antigen expression, causes dissociation of the PP2A-Shc complex, facilitating Shc phosphorylation and downstream activations of the Ras/MAP kinase pathway ; and ( iv ) that this defines a new mechanism of small-t-antigen action to promote mitogenesis
Yumoto et al., Mol Cell Biochem 2006 (Disease Progression) : Accordingly, basal PP2A contributed to the phosphorylation of Shc Tyr317 in ErbB4 expressing CHO cells, nevertheless it had been reported that PP2A negatively regulates Shc tyrosine phosphorylation in the EGF- or IGF-I induced signalling pathways