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EEF2K — PRKAB1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Horman et al., Curr Biol 2002
:
Therefore, the
activation of
eEF2 kinase by
AMPK , resulting in the phosphorylation and inactivation of eEF2, provides a novel mechanism for the inhibition of protein synthesis
Horman et al., J Biol Chem 2003
(Anoxia...) :
Human recombinant eEF2 kinase (eEF2K) was phosphorylated by
AMPK in a time- and AMP dependent fashion, and phosphorylation
led to
eEF2K activation, similar to that observed in extracts from ischemic hearts
Kruiswijk et al., Science signaling 2012
:
Here, we show that in response to genotoxic stress,
eEF2K was
activated by
AMPK ( adenosine monophosphate activated protein kinase ) -mediated phosphorylation on serine 398
Leprivier et al., Cell 2013
(Brain Neoplasms...) :
We report that
eukaryotic elongation factor 2 kinase ( eEF2K ), which is
activated by
AMP-kinase (AMPK) , confers cell survival under acute nutrient depletion by blocking translation elongation