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PRKAB1 — TNF

Text-mined interactions from Literome

Jhun et al., Biochem Biophys Res Commun 2004 : These results suggest that the effect of AICAR on TNF-alpha suppression in RAW 264.7 cells is independent of AMPK activation
Hattori et al., Hypertension 2006 : A pharmacological activator of AMPK , 5-amino-4-imidazole carboxamide riboside ( AICAR ), dose-dependently inhibited TNF-alpha- and interleukin-1beta induced NF-kappaB reporter gene expression
Li et al., Endocrinology 2007 : TNF-alpha also potently stimulated the phosphorylation of ERK1/2 and AMPK ... Treatment with SB203580 decreased p38 MAPK phosphorylation back to the baseline and restored insulin sensitivity of IRS-1 tyrosine and Akt phosphorylation and eNOS activity in TNF-alpha treated bAECs without affecting TNF-alpha induced ERK1/2 and AMPK phosphorylation ... We conclude that in cultured bAECs, TNF-alpha induces insulin resistance in the phosphatidylinositol 3-kinase/Akt/eNOS pathway via a p38 MAPK dependent mechanism and enhances ERK1/2 and AMPK phosphorylation independent of the p38 MAPK pathway
Ropelle et al., Endocrinology 2007 (Anorexia...) : In parallel, the pharmacological activation of hypothalamic AMPK in TB animals markedly reduced the hypothalamic production of inducible nitric oxide synthase, IL-1beta, and TNF-alpha and modulated the expression of proopiomelanocortin, a hypothalamic neuropeptide that is involved in the control of energy homeostasis
Łabuzek et al., Neurotoxicology 2010 : The presented evidence supports the conclusion that AMPK activated by AICAR is involved in regulation of ROS and cytokine production ( IL-1 beta, TNF-alpha ( 6h ), IL-10 and TGF-beta ) as well as arginase I and PGC-1alpha expression ... Furthermore, we found that the effects of AICAR on IL-6 and TNF-alpha ( 12, 24h ) release and on the expression of iNOS and NF-kappaB p65 are not AMPK dependent because the pre-treatment of LPS activated microglia with compound C ( a pharmacological inhibitor of AMPK ) did not reverse the effect of AICAR
Yang et al., J Biol Chem 2010 (Insulin Resistance...) : Activating AMPK signaling in macrophages by 5-aminoimidazole-4-carboxamide-1-beta4-ribofuranoside or constitutively active alpha1AMPK ( CA-alpha1 ) significantly inhibits ; although inhibiting alpha1AMPK by short hairpin RNA knock-down or dominant negative alpha1AMPK ( DN-alpha1 ) increases LPS- and FFA induced tumor necrosis factor alpha expression
Adser et al., Acta Physiol (Oxf) 2011 : In conclusion, IL-6 affects exercise induced glycogen use, AMPK signalling and TNF-a mRNA responses in mouse skeletal muscle