◀ Back to BCL2

BCL2 — TNFSF10

Pathways - manually collected, often from reviews:

• WikiPathways TP53 Network: TNFSF10 → Complex of BID-BCL2 (inhibition)

Text-mined interactions from Literome

Keogh et al., FEBS Lett 2000 : Thus, TRAIL engages a death pathway that is at least partially routed via the mitochondria, but in contrast with other stimuli that engage this pathway, TRAIL induced cytochrome c release is not regulated by Bcl-2
Neuwirtová et al., Cas Lek Cesk 2001 (Neoplasms) : So far most attention was paid to two ways of apoptosis induction of tumor cells : suppressed translation of the antiapoptic factor Bcl 2 by means of an antisense nucleotide and induction of apoptosis by TRAIL ( TNF related apoptosis inducing ligand )
Bortul et al., Leukemia 2003 : We did not observe a protective effect of Bcl-X ( L ) or Bcl-2 against the cytotoxic activity of TRAIL, even though TRAIL induced cleavage of BID
Cillessen et al., Br J Haematol 2006 (Lymphatic Metastasis...) : We conclude that hsTRAIL/Apo2L induced apoptosis in a subpopulation of chemotherapy-refractory nodal DLBCL and that disruption of the intrinsic apoptosis mediated pathway and expression of Bcl-2 and XIAP did not confer resistance to hsTRAIL/Apo2L induced apoptosis in DLBCL
Kock et al., Neoplasia (New York, N.Y.) 2007 (Glioma) : We explored the combined therapeutic effects of a secretable form of ( S ) TRAIL induced apoptosis and the downregulation of Bcl-2 in human gliomas
Lee et al., Am J Chin Med 2008 (Osteoarthritis) : In addition, Clematis mandshurica treatment prevents the Ad-TRAIL induced reduction of the interactions between 14-3-3 with phospho-ser112-Bad and phospho-ser136-Bad, and BcL-xL with phospho-ser155-Bad
Daigeler et al., Int J Oncol 2008 (Carcinoma, Squamous Cell...) : TRAIL reduced endogenous TRAIL, Bcl2l1 and caspase-1 expression
Zhang et al., Int J Cancer 2010 (Neoplasms) : We also showed that the combined therapy of TRAIL induced apoptosis and Bcl2 downregulation was superior to the mono-therapy of TRAIL or Bcl2 smRNA alone
Lee et al., Chem Biol Interact 2011 : TRAIL induced nuclear damage, decreased Bid, Bcl-2, Bcl-xL and survivin protein levels, increased Bax levels, induced cytochrome c release, activated caspases ( -8, -9 and -3 ) and increased tumor suppressor p53 levels
Lee et al., Invest New Drugs 2012 (Neoplasms, Glandular and Epithelial...) : TRAIL induced nuclear damage, decrease in Bid, Bcl-2 and Bcl-xL protein levels, increase in Bax levels, loss of the mitochondrial transmembrane potential, cytochrome c release, activation of caspases ( 8, 9 and 3 ) and increase in tumor suppressor p53 levels
Kim et al., Mol Cell Biochem 2012 (Neoplasms, Glandular and Epithelial...) : TRAIL induced a decrease in Bid, Bcl-2, Bcl-xL , and survivin protein levels, increase in Bax levels, loss of the mitochondrial transmembrane potential, cytochrome c release, activation of caspases ( -8, -9, and -3 ), cleavage of PARP-1 and an increase in the tumor suppressor p53 levels