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APP — CASP10

Text-mined interactions from Literome

Uetsuki et al., J Neurosci 1999 (Alzheimer Disease) : Here, we investigated whether APP overexpression activates caspase-3 in human postmitotic neurons using adenovirus mediated gene transfer
Yoshikawa et al., Nihon Shinkei Seishin Yakurigaku Zasshi 2000 (Alzheimer Disease...) : When APP is overexpressed in postomitotic neurons differentiated from human embryonal carcinoma by adenovirus mediated gene transfer, it induces typical apoptosis through caspase-3 activation
Nishimura et al., Cell Death Differ 2002 : We have previously reported that overexpression of wild-type APP induces caspase-3 activation and apoptosis in postmitotic neurons ... Adenovirus mediated overexpression of wild-type APP695 induced activation of caspase-3 and accumulation of APPdeltaC31 in postmitotic neurons derived from human NT2 embryonal carcinoma cells, whereas an APP mutant lacking the Abeta ( 1-20 ) region induced neither caspase-3 activation nor APPdeltaC31 generation ... These results suggest that accumulation of wild-type APP activates neuronal caspase-3 to generate APPdeltaC31 that mediates caspase-3 independent cell death
Stone et al., J Neurotrauma 2002 (Alzheimer Disease...) : Recently, caspase-3 mediated cleavage of APP and subsequent Abeta deposition was linked to apoptotic neuronal death pathways in hippocampal neurons following ischemic and excitotoxic brain injury ... By 12 h postinjury, caspase-3 mediated APP proteolysis ( CMAP ) was demonstrated within the medial lemniscus ( ML ) and medial longitudinal fasciculus ( MLF ) in axons undergoing TAI, identified by their concomitant APP accumulation ... Given that ( 1 ) APP is known to accumulate within traumatically injured axons, ( 2 ) caspase-3 activation has been demonstrated in traumatic axonal injury ( TAI ), and ( 3 ) recent studies have identified a caspase-3 cleavage site within APP, we initiated the current investigation to determine whether caspase-3 mediated cleavage of APP occurs in TAI
Ayala-Grosso et al., Brain Pathol 2002 (Alzheimer Disease...) : We utilized an antibody that selectively recognizes the neo epitope generated by caspase-3 mediated cleavage of APP ( alphadeltaC ( csp ) -APP ) to determine if this proteolytic event occurs in senile plaques in the inferior frontal gyrus and superior temporal gyrus of autopsied AD and age matched control brains
Kuwako et al., Brain Res Mol Brain Res 2002 (Alzheimer Disease...) : We have previously reported that overexpression of wild-type amyloid precursor protein (APP) in postmitotic neurons induces cleavage dependent activation of caspase-3 both in vivo and in vitro ... In this study, we investigated the mechanism underlying APP induced caspase-3 activation using adenovirus mediated gene transfer into postmitotic neurons derived from human embryonal carcinoma NT2 cells ... Chelation of intracellular Ca ( 2+ ) markedly suppressed APP induced activation of caspase-3 ... Calpain inhibitors almost completely suppressed APP induced activation of neuronal caspase-3
Venezia et al., Ann N Y Acad Sci 2004 (Alzheimer Disease...) : Our data suggest the following : ( 1 ) in normally proliferating SH-SY5Y cells, full-length APP is complexed with Grb2 [ Q3 ], likely through its SH2 domain ; ( 2 ) upon induction of apoptosis, APP is degraded and ShcA-Grb2 coimmunoprecipitates with CTFs recognized by anti-APP antibodies ; and ( 3 ) caspase inhibitors partially block the degradation of APP and the coprecipitation of CTFs with ShcA-Grb2 adaptors
Abrahamson et al., Exp Neurol 2006 (Brain Injuries...) : The present study examined the effect of caspase inhibition on post-injury levels of soluble Abeta, APP, activated caspase-3, and caspase cleaved APP in the hippocampus of nontransgenic mice expressing human Abeta, subjected to controlled cortical injury ( CCI )
Lu et al., FEBS Lett 2006 (Learning Disorders...) : Copper also caused an increase in amyloid precursor protein (APP) mRNA level and the activation of caspase-3 in the brain of cholesterol fed mice
Dong et al., Medical gas research 2011 : RNA interference mediated silencing of BACE and APP attenuates the isoflurane induced caspase activation ... We therefore set out to determine the effects of RNA interference mediated silencing of amyloid precursor protein (APP) and ß-site APP cleaving enzyme ( BACE ) on the levels of Aß and the isoflurane induced caspase-3 activation