Alves da Costa et al., J Neurochem 2004
:
Presenilin directed inhibitors of gamma-secretase trigger caspase 3 activation in presenilin expressing and presenilin-deficient cells ... Furthermore, we established that caspase 3 activation was not due to an effect of gamma-secretase inhibitors on calpains, a family of proteolytic enzymes able to modulate caspase 3 activity ... Altogether, our data demonstrate that presenilin directed gamma-secretase inhibitors affect caspase 3 activity in a presenilin independent manner
Chae et al., J Neurosci Res 2010
:
These results suggest that caspase-2 and/or -8 is involved in presenilin/gamma-secretase activation and Abeta production in apoptosis