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CASP10 — TLR4

Text-mined interactions from Literome

Mariathasan et al., Nature 2004 (Inflammation...) : Unexpectedly, Ipaf-deficient macrophages activated caspase-1 in response to TLR plus ATP stimulation but not S. typhimurium
Lemmers et al., J Biol Chem 2007 (Rhabdoviridae Infections) : In response to TLR4 stimulation, caspase-8 is recruited to a complex containing IKKalphabeta, and its loss resulted in delayed NFkappaB nuclear translocation and impaired NFkappaB transcriptional activity
Hewinson et al., J Immunol 2008 (Ion Channel Gating) : P2X(7) receptors ( P2X(7)Rs ) are ATP gated ion channels that trigger caspase-1 activation in the presence of TLR ligands
Netea et al., Blood 2009 (Inflammation) : Controversy has arisen whether Toll-like receptor ( TLR ) ligands alone can activate caspase-1 for release of interleukin-1beta (IL-1beta)
Hurst et al., Immunobiology 2009 (Antiphospholipid Syndrome) : Determination of expression-levels using real-time RT-PCR showed significantly augmented TLR dependent IL-1beta and caspase-1 expression
Nowicki et al., J Neurosci Res 2010 : The inhibition of TLR4 caused activation of jun N-terminal kinase ( JNK ) and a significant decrease of cleaved caspase-3 but did not change the TLR4 level
Harder et al., J Immunol 2009 (Disease Models, Animal...) : Notably, activation of caspase-1 by TLR2 and TLR4 ligands in the presence of streptolysin O required Myd88/Trif, whereas that induced by S. pyogenes was blocked by inhibition of NF-kappaB