◀ Back to FOXO1

FOXO1 — PTEN

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: FOXO1 → PTEN (increases, PTEN Translocation)
  Evidence: when PTEN is exogenously expressed, FOXO1 relocates to the nucleus and restores transcriptional activation (Nakamura et al., 2000).
• OpenBEL Selventa BEL large corpus: FOXO1 → PTEN (increases, PTEN Activity)
  Evidence: In PTEN-deficient prostate carcinoma cell lines, FOXO1 and FOXO3 are cytoplasmically sequestered and inactive (Modur et al., 2002). In addition, the expression level of tumor necrosis factor family member TRAIL (tumor necrosis factor-related apoptosis-inducing ligand; Modur et al., 2002), a proapoptotic effector, is decreased (Modur et al., 2002).
• OpenBEL Selventa BEL large corpus: FOXO1 → PTEN (increases, PTEN Activity, FOXO1 Activity) Li et al., Mol Cell Biol 2003*
  Evidence: Modified assertion

Text-mined interactions from Literome

Jomary et al., Invest Ophthalmol Vis Sci 2006 (Retinal Degeneration) : In the period up to the peak of photoreceptor apoptosis at postnatal day 15, dysregulation of the survival pathway was identified at several levels, including deactivation of both Akt itself and its downstream transcription factor target Forkhead ( FKHR ) and activation of the upstream negative regulator PTEN
Ma et al., Mol Endocrinol 2009 : FoxO1 mediates PTEN suppression of androgen receptor N- and C-terminal interactions and coactivator recruitment
Kamo et al., Hepatology 2013 (Liver Diseases...) : This study was designed to investigate the role of PTEN mediated Akt/ß-catenin/Foxo1 signaling in the regulation of in vivo and in vitro innate immune responses in a mouse model of hepatic inflammatory injury induced by 90 minutes of liver partial warm ischemia followed by 6 hours of reperfusion ... By identifying molecular mechanisms of PTEN mediated Akt/ß-catenin/Foxo1 signaling in TLR4 innate immune regulation, our study provides a rationale for therapeutic approaches to manage inflammation injury in IR-stressed liver
Wu et al., Prostate 2013 (Prostatic Neoplasms) : Luciferase assays were used to determined the FOXO1 transactivity and the direct regulation of PTEN-3'-UTR by miR-153