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AKT2 — PLD2

Text-mined interactions from Literome

Wang et al., Biochem Pharmacol 2003 : Collectively, these results indicate that the inhibition by CCY1a of fMLP induced O2 ( .- ) generation in rat neutrophils can probably be attributed to the increase in cAMP levels, and to the blockade of Ca2+ entry, suppression of Akt , and PLD activation via cAMP independent mechanisms
Kam et al., FASEB J 2004 : PDGF induced marked phosphorylation of Akt ( a PI3K target ) but this was not affected by PLD deficiency ... LPA caused much less phosphorylation of Akt and this was dependent on PLD activity
Li et al., J Pharmacol Exp Ther 2005 : Diacylglycerol kinase inhibitor II diminished Ang II-induced and diC8-phosphatidic acid ( PA ) -increased Akt phosphorylation, suggesting that PLD dependent Akt activation is mediated by PA ... These data indicate that Ang II-stimulated Akt activity is mediated by cPLA(2) dependent, p38 MAPK regulated PLD(2) activation and EGFR transactivation
Banno et al., J Biol Chem 2005 : Furthermore, the PI3K/Akt activation in response to H ( 2 ) O ( 2 ) was reduced by transfection of either PLD2KR or the dominant negative Pyk2DN
Li et al., Am J Physiol Heart Circ Physiol 2005 (Carotid Artery Injuries) : ANG II-induced neointimal growth is mediated via cPLA2- and PLD2 activated Akt in balloon injured rat carotid artery ... This study was conducted to determine whether ANG II-induced neointimal thickening is mediated via cPLA2- and PLD2 activated Akt in balloon injured rat carotid arteries
Kim et al., Cancer Res 2006 : Etoposide induced activation of Akt was potentiated by overexpression of PLD and PLD stimulated suppression of Egr-1 was blocked by inhibition of phosphatidylinositol 3-kinase/Akt survival pathway at the both transcriptional and posttranscriptional levels
Di Fulvio et al., Cell Signal 2008 : Transient expression of PLD2 in COS7 cells with either the WT or with a Y179F mutant, resulted in an increased basal phosphorylation of AKT in residues T308 and S473, in a PI3K dependent manner
Toschi et al., Mol Cell Biol 2009 : Suppression of PLD also blocked insulin stimulated Akt phosphorylation at Ser473 and the mTORC2 dependent phosphorylation of PRAS40