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CCDC88A — STAT3
Text-mined interactions from Literome
Dunkel et al., J Biol Chem 2012
(Breast Neoplasms...) :
STAT3 protein up-regulates Ga-interacting vesicle associated protein ( GIV ) /Girdin expression, and
GIV enhances
STAT3 activation in a positive feedback loop during wound healing and tumor invasion/metastasis
Cardoso et al., PloS one 2012
(Adenocarcinoma...) :
Overall, this work demonstrates that the transcriptional activity of
STAT3 is directly
regulated by the redox function of
APE1/Ref-1 , and that concurrent blockade of STAT3 and APE1/Ref-1 redox synergize effectively inhibit critical PDAC cell functions