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FGF2 — STAT3

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: STAT3 → FGF2 (increases) Ishikawa et al., J Clin Exp Hematop 2006*
  Evidence: enhanced proliferation of KMS-11. bFGF but not IL-6 stimu- lation induces the phosphorylation of Ser727 in STAT3, and a selective MEK1/2 inhibitor abolishes the serine- but not tyrosine-phosphorylation of STAT3 in response to bFGF and IL-6 stimulations, supportingthe notion that two independent signaling pathways converge on STAT3 to regulate its func- tion in the cell. Thus, the bFGF-induced activation of ERK1/ 2 pathway is involved in the phosphorylation of the critical serine residue of STAT3...

Text-mined interactions from Literome

Paradis et al., J Cell Sci 2000 : LIF stimulation of IEM cells leads to activation of the Stat3 as well as the ( P41/43 ) mitogen activated protein kinase ( ( P41/43 ) MAPK ) cascade, while bFGF does not activate Stat3 but does induce the ( P41/43 ) MAPK cascade
Ishikawa et al., Oncogene 2005 (Multiple Myeloma...) : Furthermore, the FGF induced activation of ERK 1/2 contributed to the serine phosphorylation of STAT 3 , suggesting that the signaling crosstalk between the cytokine receptor, IL-6 receptor alpha/gp 130 and the growth factor receptor tyrosine kinase, FGFR 3
Zhang et al., Exp Eye Res 2005 : Retinas from embryonic and neonatal stages showed that STAT3 but not STAT1 was activated in response to ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), fibroblast growth factor-1 (FGF1), fibroblast growth factor-2 (FGF2) , epidermal growth factor (EGF), interferon-alpha ( IFN-alpha ) and interferon-gamma (IFN-gamma) in distinct patterns
Cao et al., Circ Res 2006 : An increased association of STAT-5B with STAT-3 occurred in response to thrombin and adenovirus mediated expression of dnSTAT-3 suppressed thrombin induced Hsp27 and FGF-2 induction, DNA synthesis and motility in VSMC ... Together, these results indicate that thrombin induced VSMC growth and motility require STAT-5B/STAT-3 dependent expression of Hsp27 and FGF-2
Xie et al., Cancer Res 2006 (Brain Neoplasms...) : Furthermore, altered Stat3 activity profoundly affected melanoma angiogenesis in vivo and melanoma cell invasion in vitro and significantly affected the expression of basic fibroblast growth factor (bFGF) , vascular endothelial growth factor ( VEGF ), and matrix metalloproteinase-2 (MMP-2) in vivo and in vitro ... Finally, Stat3 activity transcriptionally regulated the promoter activity of bFGF in addition to VEGF and MMP-2 in human melanoma cells ... These results indicated that Stat3 activation plays an important role in dysregulated expression of bFGF , VEGF, and MMP-2 as well as angiogenesis and invasion of melanoma cells and contributes to brain metastasis of melanoma
Li et al., Clin Cancer Res 2006 (Carcinoma, Hepatocellular...) : In mice bearing orthotopically implanted HCCLM3, STAT3 inhibition following therapeutic treatment with STAT3 ASO reduced circulating vascular endothelial growth factor and basic fibroblast growth factor , decreased intratumor CD34 positive microvessel density, intrahepatic and intraperitoneal transmission, and lung metastasis ... In mice bearing orthotopically implanted HCCLM3, STAT3 inhibition following therapeutic treatment with STAT3 ASO reduced circulating vascular endothelial growth factor and basic fibroblast growth factor , decreased intratumor CD34 positive microvessel density, intrahepatic and intraperitoneal transmission, and lung metastasis
Krejci et al., J Cell Sci 2008 : However, as demonstrated by western blotting with phosphorylation-specific antibodies, imaging of STAT nuclear translocation, STAT transcription factor assays and STAT luciferase reporter assays, FGF does not activate STAT1 or STAT3 in RCS chondrocytes, which nevertheless respond to a FGF stimulus with potent growth arrest
Krejci et al., Cell Signal 2009 : Despite the accumulation, both endogenous and cytokine induced activation of STAT1 and STAT3 is impaired by FGF , as demonstrated by imaging of active STAT nuclear translocation and analyses of STAT activatory phosphorylation and transcriptional activation
Chen et al., Cancer Biol Ther 2008 (Neoplasms...) : FGF2 but not PlGF also induced EC STAT3 activation in vitro
Bhatnagar et al., J Biol Chem 2009 : In contrast, FGF-19 increased the activity of STAT3 , an inhibitor of SREBP-1c expression and decreased the expression of peroxisome proliferator activated receptor-gamma coactivator-1beta ( PGC-1beta ), an activator of SREBP-1c activity
Puhr et al., Endocr Relat Cancer 2010 (Carcinoma...) : In the presence of FGF-2 , neither STAT3 , STAT1, nor Akt could be phosphorylated
Liu et al., J Exp Clin Cancer Res 2011 (Brain Neoplasms...) : In the current study, we found that in glioma cells U251, Ad-bFGF-siRNA impedes the activation of ERK1/2 and JAK2, but not Src, decreases IL-6 secretion, reduces STAT3 phosphorylation, decreases the levels of downstream molecules CyclinD1 and Bcl-xl, and ultimately results in the collapse of mitochondrial membrane potentials as well as the induction of mitochondrial related apoptosis
Megeney et al., Dev Genet 1996 : Similarly, bFGF stimulation of myoblasts resulted in the tyrosine phosphorylation of STAT3 ... However, unlike LIF, the bFGF induced tyrosine phosphorylation of STAT3 appeared cyclical, with recurrent peaks of phosphorylation even after prolonged exposure