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FGF8 — STAT3
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Ishikawa et al., Oncogene 2005
(Multiple Myeloma...) :
Furthermore, the
FGF induced activation of ERK 1/2
contributed to the serine phosphorylation of
STAT 3 , suggesting that the signaling crosstalk between the cytokine receptor, IL-6 receptor alpha/gp 130 and the growth factor receptor tyrosine kinase, FGFR 3
Li et al., Clin Cancer Res 2006
(Carcinoma, Hepatocellular...) :
In mice bearing orthotopically implanted HCCLM3,
STAT3 inhibition following therapeutic treatment with STAT3 ASO
reduced circulating vascular endothelial growth factor and basic
fibroblast growth factor , decreased intratumor CD34 positive microvessel density, intrahepatic and intraperitoneal transmission, and lung metastasis
Krejci et al., J Cell Sci 2008
:
However, as demonstrated by western blotting with phosphorylation-specific antibodies, imaging of STAT nuclear translocation, STAT transcription factor assays and STAT luciferase reporter assays,
FGF does not
activate STAT1 or
STAT3 in RCS chondrocytes, which nevertheless respond to a FGF stimulus with potent growth arrest
Krejci et al., Cell Signal 2009
:
Despite the accumulation, both endogenous and cytokine induced activation of STAT1 and
STAT3 is
impaired by
FGF , as demonstrated by imaging of active STAT nuclear translocation and analyses of STAT activatory phosphorylation and transcriptional activation
Bhatnagar et al., J Biol Chem 2009
:
In contrast,
FGF-19 increased the activity of
STAT3 , an inhibitor of SREBP-1c expression and decreased the expression of peroxisome proliferator activated receptor-gamma coactivator-1beta ( PGC-1beta ), an activator of SREBP-1c activity