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ILK — STAT3

Text-mined interactions from Literome

Yau et al., Cancer Res 2005 (Neovascularization, Pathologic...) : Inhibition of integrin linked kinase by a selective small molecule inhibitor, QLT0254, inhibits the PI3K/PKB/mTOR, Stat3 , and FKHR pathways and tumor growth, and enhances gemcitabine induced apoptosis in human orthotopic primary pancreatic cancer xenografts
Wani et al., Oncogene 2011 (Melanoma...) : As STAT3 binds to vascular endothelial growth factor ( VEGF ) promoter, we found that VEGF levels were elevated in ILK overexpressing cells and declined upon transfection of IL-6 small interfering RNA, suggesting that ILK may regulate VEGF expression through IL-6 pathway by activating STAT3