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PDLIM7 — STAT3

Text-mined interactions from Literome

Chen et al., J Virol 2003 : The previous observation that STAT3 activated the LMP1 terminal repeat promoter in reporter assays was extended to show upregulated expression of endogenous LMP1 mRNA and protein in HeLa-Bx1 cells transfected with a constitutively activated STAT3
Buettner et al., Virchows Arch 2006 (Nasopharyngeal Neoplasms) : It was proposed recently that LMP1 expression in epithelial cells may be regulated through a loop involving activated signal transducer and activator of transcription 3 ( STAT3 ), LMP1, LMP1 mediated induction of interleukin (IL)-6 expression and STAT3 activation through the IL-6 receptor
Liu et al., Int J Mol Med 2008 (Nasopharyngeal Neoplasms) : Demonstration of the involvement of different kinases in LMP1 induced STAT3 activation supports the involvement of the JAK/STAT and mitogen activated protein kinase ( MAPK ) /ERK signaling pathways in the regulation of STAT3 activation by LMP1
Kung et al., J Virol 2008 : LMP1-CTAR1 constitutively activates STAT3 , and this activation was not due to the induction of interleukin 6 (IL-6) ... In addition to activating the canonical and noncanonical pathways, LMP1-CTAR1 constitutively activates STAT3 and increases Bcl-3
Hino et al., Cancer Res 2009 (Epstein-Barr Virus Infections...) : Taken together, LMP2A induces the phosphorylation of STAT3 , which activates DNMT1 transcription and causes PTEN expression loss through CpG island methylation of the PTEN promoter in EBV associated GC
Wang et al., Eur J Cancer 2010 (Nasopharyngeal Neoplasms...) : The fundamental molecular mechanisms of LMP1 regulated STAT3 activation in NPC cell invasion have not been completely explored ... Induction of STAT3 by the human viral oncoprotein LMP1 may contribute to the invasion of NPC
Kung et al., J Virol 2011 : Epstein-Barr virus LMP1 activates EGFR, STAT3 , and ERK through effects on PKCdelta ... EGFR transcription is induced by LMP1 through a p50 NF?B1-Bcl-3 complex, and Bcl-3 is induced by LMP1 mediated activation of STAT3 ... The kinase responsible for LMP1-CTAR1 mediated serine phosphorylation of STAT3 was identified to be PKCd using specific RNAi, a dominant negative PKCd, and the PKCd inhibitor rottlerin