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STAT3 — STK11
Text-mined interactions from Literome
Kim et al., Mol Endocrinol 2007
(Carcinoma, Papillary...) :
This study examines the
effect of
LKB1 on regulation of
STAT3 and expression of transcriptional targets of STAT3 ... Suppression of
STAT3 transactivation by LKB1
requires the kinase domain but not the kinase activity of
LKB1
Zemskova et al., J Biol Chem 2008
(Prostatic Neoplasms) :
Docetaxel activates
STAT3 phosphorylation and transcriptional activity, which in turns
induces expression of the PIM1 gene, encoding a
serine-threonine kinase activated by many cellular stresses
Liang et al., Oncol Rep 2009
(Lung Neoplasms...) :
Overexpression of the
LKB1 gene could
inhibit the activation of ERK1/2 and
STAT3 signaling pathways involved in the cell proliferation
Hegde et al., Oncogene 2009
(Leukemia, Erythroblastic, Acute) :
We demonstrate here that
activation of
Stat3 by
Sf-Stk in the early stage of disease is essential for the progression of erythroleukemia in the presence of differentiation signals induced by the EpoR, but is dispensable in the late stages of the disease
Yu et al., Atherosclerosis 2012
(Carotid Artery Injuries...) :
AMPK activation is promoted by
liver kinase B1 (LKB1) , and LKB1
inhibits STAT3 activation