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Cabart et al., Oncogene 2004
:
Cyclin T1 is required for BRCA1- and NUFIP dependent synergistic activation of pol II transcription in 293 cells
Moisan et al., J Biol Chem 2006
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Here, we investigate the effect of BRCA1 on serine 2 phosphorylation and UV-activated P-TEFb kinase activity ... We now show that BRCA1 inhibits immunoprecipitated P-TEFb kinase activity from UV-irradiated cells and preferentially decreases UV-induced serine 2 phosphorylation of soluble, rather than chromatin bound, RNAPII