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BRCA1 — PARP1

Text-mined interactions from Literome

Tong et al., Oncogene 2007 (Cell Transformation, Neoplastic...) : In addition, PARP-1 deficiency compromises p53 activation and impairs BRCA1 recruitment to the sites of DNA damage in PME cells ... In addition, PARP-1 deficiency compromises p53 activation and impairs BRCA1 recruitment to the sites of DNA damage in PME cells
Hegan et al., Proc Natl Acad Sci U S A 2010 (Colonic Neoplasms) : However, we also report the unexpected finding that disruption of PARP , itself, either via chemical PARP inhibitors or siRNAs targeted to PARP-1, can inhibit HDR by suppressing expression of BRCA1 and RAD51, key factors in HDR of DNA breaks