◀ Back to BRCA1
BRCA1 — TP53BP1
Pathways - manually collected, often from reviews:
-
FastForward regulation:
TP53BP1
→
BRCA1
(transcriptional regulation, unknown)
Rauch et al., Cell cycle (Georgetown, Tex.) 2005*
Evidence: DNABINDING
-
NCI Pathway Database ATM pathway:
MRN complex/ATM/MDC1/H2AX/RNF8/53BP1/BRCA1 complex (MRE11A-NBN-RAD50-ATM-H2AFX-MDC1-RNF8-TP53BP1-BRCA1)
→
MRN complex/ATM/MDC1/H2AX/RNF8/53BP1/BRCA1/ABRA1 complex (MRE11A-NBN-RAD50-ATM-H2AFX-MDC1-RNF8-TP53BP1-BRCA1-FAM175A)
(modification, collaborate)
Wang et al., Science 2007
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database ATM pathway:
MRN complex/ATM/MDC1/H2AX/RNF8/53BP1/BRCA1 complex (MRE11A-NBN-RAD50-ATM-H2AFX-MDC1-RNF8-TP53BP1-BRCA1)
→
ABRA1 (FAM175A)
(modification, collaborate)
Wang et al., Science 2007
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database ATM pathway:
MRN complex/ATM/MDC1/H2AX/RNF8/53BP1/BRCA1/ABRA1 complex (MRE11A-NBN-RAD50-ATM-H2AFX-MDC1-RNF8-TP53BP1-BRCA1-FAM175A)
→
ABRA1 (FAM175A)
(modification, collaborate)
Wang et al., Science 2007
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database ATM pathway:
MRN complex/ATM/MDC1/H2AX/RNF8/53BP1/BRCA1 complex (MRE11A-NBN-RAD50-ATM-H2AFX-MDC1-RNF8-TP53BP1-BRCA1)
→
MRN complex/ATM/MDC1/H2AX/RNF8/53BP1 complex (MRE11A-NBN-RAD50-ATM-H2AFX-MDC1-RNF8-TP53BP1)
(modification, collaborate)
Cortez et al., Science 1999, Li et al., Nature 2000, Xu et al., Mol Cell Biol 2001, Stewart et al., Nature 2003, Lou et al., J Biol Chem 2003, Mailand et al., Cell 2007, Huen et al., Cell 2007, Kolas et al., Science 2007
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database ATM pathway:
MRN complex/ATM/MDC1/H2AX/RNF8/53BP1/BRCA1 complex (MRE11A-NBN-RAD50-ATM-H2AFX-MDC1-RNF8-TP53BP1-BRCA1)
→
CtBP/CtIP complex (RBBP8)
(modification, collaborate)
Cortez et al., Science 1999, Li et al., Nature 2000, Xu et al., Mol Cell Biol 2001, Stewart et al., Nature 2003, Lou et al., J Biol Chem 2003, Mailand et al., Cell 2007, Huen et al., Cell 2007, Kolas et al., Science 2007
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database ATM pathway:
MRN complex/ATM/MDC1/H2AX/RNF8/53BP1/BRCA1 complex (MRE11A-NBN-RAD50-ATM-H2AFX-MDC1-RNF8-TP53BP1-BRCA1)
→
BRCA1/CtBP/CtIP complex (BRCA1-CTBP1-RBBP8)
(modification, collaborate)
Cortez et al., Science 1999, Li et al., Nature 2000, Xu et al., Mol Cell Biol 2001, Stewart et al., Nature 2003, Lou et al., J Biol Chem 2003, Mailand et al., Cell 2007, Huen et al., Cell 2007, Kolas et al., Science 2007
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database ATM pathway:
MRN complex/ATM/MDC1/H2AX/RNF8/53BP1 complex (MRE11A-NBN-RAD50-ATM-H2AFX-MDC1-RNF8-TP53BP1)
→
BRCA1/CtBP/CtIP complex (BRCA1-CTBP1-RBBP8)
(modification, collaborate)
Cortez et al., Science 1999, Li et al., Nature 2000, Xu et al., Mol Cell Biol 2001, Stewart et al., Nature 2003, Lou et al., J Biol Chem 2003, Mailand et al., Cell 2007, Huen et al., Cell 2007, Kolas et al., Science 2007
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database ATM pathway:
MRN complex/ATM/MDC1/H2AX/RNF8/53BP1/BRCA1/ABRA1/RAP80 complex (MRE11A-NBN-RAD50-ATM-H2AFX-MDC1-RNF8-TP53BP1-BRCA1-FAM175A-UIMC1)
→
RAP80 (UIMC1)
(modification, collaborate)
Wang et al., Science 2007, Mailand et al., Cell 2007, Huen et al., Cell 2007, Kolas et al., Science 2007
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database ATM pathway:
MRN complex/ATM/MDC1/H2AX/RNF8/53BP1/BRCA1/ABRA1/RAP80 complex (MRE11A-NBN-RAD50-ATM-H2AFX-MDC1-RNF8-TP53BP1-BRCA1-FAM175A-UIMC1)
→
MRN complex/ATM/MDC1/H2AX/RNF8/53BP1/BRCA1/ABRA1 complex (MRE11A-NBN-RAD50-ATM-H2AFX-MDC1-RNF8-TP53BP1-BRCA1-FAM175A)
(modification, collaborate)
Wang et al., Science 2007, Mailand et al., Cell 2007, Huen et al., Cell 2007, Kolas et al., Science 2007
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database ATM pathway:
RAP80 (UIMC1)
→
MRN complex/ATM/MDC1/H2AX/RNF8/53BP1/BRCA1/ABRA1 complex (MRE11A-NBN-RAD50-ATM-H2AFX-MDC1-RNF8-TP53BP1-BRCA1-FAM175A)
(modification, collaborate)
Wang et al., Science 2007, Mailand et al., Cell 2007, Huen et al., Cell 2007, Kolas et al., Science 2007
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database ATM pathway:
MRN complex/ATM/MDC1/H2AX/RNF8/53BP1/BRCA1 complex (MRE11A-NBN-RAD50-ATM-H2AFX-MDC1-RNF8-TP53BP1-BRCA1)
→
SMC1 (SMC1A)
(modification, activates)
Kim et al., Genes Dev 2002, Yazdi et al., Genes Dev 2002, Kitagawa et al., Genes Dev 2004
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database ATM pathway:
MRN complex/ATM/MDC1/H2AX/RNF8/53BP1/BRCA1 complex (MRE11A-NBN-RAD50-ATM-H2AFX-MDC1-RNF8-TP53BP1-BRCA1)
→
SMC3 (SMC3)
(modification, activates)
Luo et al., J Biol Chem 2008
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database ATM pathway:
MRN complex/ATM/MDC1/H2AX/RNF8/53BP1/BRCA1 complex (MRE11A-NBN-RAD50-ATM-H2AFX-MDC1-RNF8-TP53BP1-BRCA1)
→
MRN complex/ATM/MDC1/H2AX/RNF8/53BP1 complex (MRE11A-NBN-RAD50-ATM-H2AFX-MDC1-RNF8-TP53BP1)
(modification, collaborate)
Li et al., Nature 2000, Xu et al., Cancer Res 2002, Stewart et al., Nature 2003, Mailand et al., Cell 2007, Huen et al., Cell 2007, Kolas et al., Science 2007
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database ATM pathway:
MRN complex/ATM/MDC1/H2AX/RNF8/53BP1/BRCA1 complex (MRE11A-NBN-RAD50-ATM-H2AFX-MDC1-RNF8-TP53BP1-BRCA1)
→
CtBP/CtIP complex (RBBP8)
(modification, collaborate)
Li et al., Nature 2000, Xu et al., Cancer Res 2002, Stewart et al., Nature 2003, Mailand et al., Cell 2007, Huen et al., Cell 2007, Kolas et al., Science 2007
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database ATM pathway:
MRN complex/ATM/MDC1/H2AX/RNF8/53BP1/BRCA1 complex (MRE11A-NBN-RAD50-ATM-H2AFX-MDC1-RNF8-TP53BP1-BRCA1)
→
BRCA1/CtBP/CtIP complex (BRCA1-CTBP1-RBBP8)
(modification, collaborate)
Li et al., Nature 2000, Xu et al., Cancer Res 2002, Stewart et al., Nature 2003, Mailand et al., Cell 2007, Huen et al., Cell 2007, Kolas et al., Science 2007
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database ATM pathway:
MRN complex/ATM/MDC1/H2AX/RNF8/53BP1 complex (MRE11A-NBN-RAD50-ATM-H2AFX-MDC1-RNF8-TP53BP1)
→
BRCA1/CtBP/CtIP complex (BRCA1-CTBP1-RBBP8)
(modification, collaborate)
Li et al., Nature 2000, Xu et al., Cancer Res 2002, Stewart et al., Nature 2003, Mailand et al., Cell 2007, Huen et al., Cell 2007, Kolas et al., Science 2007
Evidence: mutant phenotype, assay, physical interaction
-
Reactome Reaction:
BRCA1
→
TP53BP1
(reaction)
Yamane et al., Mol Cell Biol 2002*, Wang et al., Science 2002*, West et al., Nat Rev Mol Cell Biol 2003*
-
Reactome Reaction:
BRCA1
→
TP53BP1
(indirect_complex)
Yamane et al., Mol Cell Biol 2002*, Wang et al., Science 2002*, West et al., Nat Rev Mol Cell Biol 2003*
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
TP53BP1
—
BRCA1
(physical association, affinity chromatography technology)
Matsuoka et al., Science 2007
-
IRef Biogrid Interaction:
TP53BP1
—
BRCA1
(physical association, affinity chromatography technology)
Wang et al., Science 2002*
-
IRef Biogrid Interaction:
TP53BP1
—
BRCA1
(colocalization, imaging technique)
Bohgaki et al., PLoS Genet 2011*
-
IRef Hprd Interaction:
TP53BP1
—
BRCA1
(in vivo)
Wang et al., Science 2002*
-
IRef Intact Interaction:
TP53BP1
—
BRCA1
(physical association, anti bait coimmunoprecipitation)
Matsuoka et al., Science 2007
-
IRef Intact Interaction:
TP53BP1
—
BRCA1
(colocalization, confocal microscopy)
Mailand et al., Cell 2007
-
IRef Intact Interaction:
TP53BP1
—
BRCA1
(colocalization, confocal microscopy)
Gudjonsson et al., Cell 2012*
-
IRef Intact Interaction:
Complex of RAD50-CHEK2-TP53BP1-BRCA1-GINS2
(association, anti bait coimmunoprecipitation)
Matsuoka et al., Science 2007
-
STRING interaction:
BRCA1
—
TP53BP1
(interaction, mapped from kegg_pathways)
-
STRING interaction:
TP53BP1
—
BRCA1
(interaction, mapped from kegg_pathways)
Text-mined interactions from Literome
Rauch et al., Cell cycle (Georgetown, Tex.) 2005
(Breast Neoplasms...) :
These findings establish a positive
regulation of the
BRCA1 promoter by
53BP1
Corkery et al., BMC biochemistry 2011
:
Regulation of the
BRCA1 gene by an
SRC3/53BP1 complex ... However using chromatin immunoprecipitation ( ChIP ) and siRNA knockdown, we have demonstrated that both SRC3 and
53BP1 co-occupy the same region of the BRCA1 promoter and both are
required for
BRCA1 expression in HeLa cells
Grotsky et al., J Cell Biol 2013
(Breast Neoplasms...) :
BRCA1 loss
activates cathepsin L-mediated degradation of
53BP1 in breast cancer cells ... Here, we demonstrate that
BRCA1 loss
activates cathepsin L (CTSL) mediated degradation of
53BP1