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NOS3 — PGC
Text-mined interactions from Literome
Geng et al., Am J Pathol 2011
(Cachexia) :
In addition to inactivation of forkhead transcription factor signaling through enhanced Akt/protein kinase B expression, in glycolytic muscles,
PGC-1a overexpression
led to enhanced expression of inducible
nitric oxide synthase and endothelial nitric oxide synthase, production of nitric oxide, and expression of antioxidant enzyme including superoxide dismutases ( SOD1, SOD2, and SOD3 ) and catalase, and reduced oxidative stress
Ye et al., Cardiovasc Drugs Ther 2011
(Diabetes Mellitus, Experimental...) :
Both AL and VA reduced myocardial AT1R levels, without affecting AT2R levels, and
increased the expression of Sirt1 and
PGC-1a with increased phosphorylation of Akt and
eNOS