UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to SIRT1

PPARA — SIRT1

Pathways - manually collected, often from reviews:

WikiPathways SREBF and miR33 in cholesterol and lipid homeostasis: SIRT1 → PPARA (activation)

Text-mined interactions from Literome

Shakibaei et al., PloS one 2012 : Activation of Sirt-1 by resveratrol in MSCs increased its binding to PPAR-? and repressed PPAR-? activity by involving its cofactor NCoR ( nuclear receptor co-repressor )
Kim et al., Biochem Pharmacol 2012 : In addition, activation of PPARd, but not PPARa or PPAR? , significantly enhanced SIRT1 promoter activity and protein expression