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CEBPB — SMAD3

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: CEBPB → Complex of SMAD3-SMAD4 (decreases, SMAD3/SMAD4 Activity) Zauberman et al., J Biol Chem 2001*
  Evidence: This was abolished by either a constitutively active form of activin A type IB receptor (CAactRIB) or by a combination of Smad3 and Smad4.
• NCI Pathway Database Regulation of nuclear SMAD2/3 signaling: CEBPB (CEBPB) → SMAD3/E2F4-5/DP1/p107/SMAD4 complex (SMAD3-E2F5_E2F4-TFDP1-RBL1-SMAD4) (negative regulation of cell growth, activates)
  Chen et al., Cell 2002, Frederick et al., Mol Cell Biol 2004, Gomis et al., Cancer Cell 2006
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database Regulation of nuclear SMAD2/3 signaling: SMAD2-3/SMAD4/FOXO1-3a-4/CEBPB complex (SMAD2_SMAD3-SMAD4-FOXO3_FOXO4_FOXO1-CEBPB) → p15INK4b (CDKN2B) (transcription, activates) Gomis et al., Cancer Cell 2006
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database Regulation of nuclear SMAD2/3 signaling: SMAD2-3/SMAD4/FOXO1-3a-4/CEBPB complex (SMAD2_SMAD3-SMAD4-FOXO3_FOXO4_FOXO1-CEBPB) → CEBPB (CEBPB) (modification, collaborate) Gomis et al., Cancer Cell 2006
  Evidence: physical interaction
• NCI Pathway Database Regulation of nuclear SMAD2/3 signaling: SMAD2-3/SMAD4/FOXO1-3a-4/CEBPB complex (SMAD2_SMAD3-SMAD4-FOXO3_FOXO4_FOXO1-CEBPB) → SMAD2-3/SMAD4/FOXO1-3a-4 complex (SMAD2_SMAD3-SMAD4-FOXO3_FOXO4_FOXO1) (modification, collaborate)
  Gomis et al., Cancer Cell 2006
  Evidence: physical interaction
• NCI Pathway Database Regulation of nuclear SMAD2/3 signaling: CEBPB (CEBPB) → SMAD2-3/SMAD4/FOXO1-3a-4 complex (SMAD2_SMAD3-SMAD4-FOXO3_FOXO4_FOXO1) (modification, collaborate)
  Gomis et al., Cancer Cell 2006
  Evidence: physical interaction
• WikiPathways Ovarian Infertility Genes: SMAD3 → PGR/ESR2/VDR/NR5A1/TBP/NCOR1/NRIP1/EGR1/CEBPB (activation)
  

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: CEBPB — SMAD3 (direct interaction, pull down) Choy et al., J Biol Chem 2003*
• IRef Hprd Interaction: CEBPB — SMAD3 (in vitro) Choy et al., J Biol Chem 2003*
• IRef Intact Interaction: SMAD3 — CEBPB (direct interaction, pull down) Coyle-Rink et al., Virology 2002*
• IRef Ophid Interaction: SMAD3 — CEBPB (aggregation, confirmational text mining) Coyle-Rink et al., Virology 2002*
• IRef Ophid Interaction: SMAD3 — CEBPB (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: SMAD3 — CEBPB (aggregation, confirmational text mining) Choy et al., J Biol Chem 2003*

Text-mined interactions from Literome

Nerlov et al., Curr Opin Cell Biol 2008 : Finally, interaction with Smad proteins, which are accumulated in the nucleus upon TGFbeta or BMP signaling, may lead to the formation of C/EBP-Smad complexes and activation of Smad-C/EBPbeta coregulated promoters, while at the same time inhibiting other C/EBP dependent transcription
Abraham et al., J Interferon Cytokine Res 2009 : Interestingly, expression of Smad3 and Smad4, the downstream regulators of the TGF-beta1 signaling pathway, impairs the activity of C/EBPbeta on the TGF-beta1 promoter