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CASP10 — TRAF2
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Hentze et al., Hepatology 2004
:
CPT treatment completely abrogated the TNF induced NF-kappa B activation, and mRNA expression of the antiapoptotic factors
TNF-receptor associated factor 2 , FLICE-inhibitory protein, and X-linked inhibitor of apoptosis protein was also
inhibited by CPT. The
caspase inhibitors benzyloxycarbonyl-Val-Ala-Asp- ( OMe ) -fluoromethylketone ( zVAD-fmk ) and benzyloxycarbonyl-Asp ( OMe ) -Glu ( OMe ) -Val-Asp ( OMe ) -chloromethylketone ( zDEVD-fmk ), as well as depletion of intracellular ATP by fructose prevented CPT/TNF induced apoptosis
Conti et al., J Neurosurg 2005
(Brain Neoplasms...) :
The authors investigated the expression of NF-kappaB,
caspase 3, TRAF1, TRAF2, and TRAF associated NF-kappaB activator/TRAF interacting protein ( TANK/I-TRAF ), a
regulator of
TRAF activity, in human gliomas
Georgopoulos et al., Cell Death Differ 2006
(Urologic Neoplasms) :
Thus,
TRAF3 stabilization, JNK activation and
caspase-9 induction define a novel pathway of CD40 mediated apoptosis in carcinoma cells