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ABCC1 — IL6
Text-mined interactions from Literome
Vellenga et al., Br J Pharmacol 1999
:
4. These results indicate that the membrane transporter
MRP1 is
involved in the regulation of
IL-6 expression in activated human peripheral blood monocytes
Kim et al., Shock 2000
(Cholestasis, Intrahepatic...) :
We conclude that 1 ) Ntcp and Mrp2 transcription is down-regulated transiently after CLP and persistently after 2CLP ; 2 ) 2CLP results in hyperbilirubinemia and cholestasis, in part due to persistently decreased transcription of Ntcp and Mrp2 ; and 3 ) altered Ntcp and
Mrp2 transcription is
mediated in part by
IL-6
Lee et al., Can J Physiol Pharmacol 2001
(Carcinoma, Hepatocellular...) :
Our data suggest that
IL-6 induces
MRP expression and activity in human hepatoma cell lines
Jacobs et al., Skin Pharmacol Physiol 2004
(Warts) :
Analysis of imiquimod treated warts demonstrated that imiquimod enhanced
IL-6 expression and
induced IL-8, GM-CSF,
MRP-8 and MRP-14
Andrejko et al., Shock 2008
(Sepsis) :
Recombinant human
IL-6 restored the sepsis induced decrease in Ntcp,
MRP-2 , OATP, and HNF-1alpha expression in IL-6 -/- mice
Ogura et al., Life Sci 2008
(Reperfusion Injury) :
These results suggest that the decreased
Mrp2 expression after intestinal I/R was
regulated by
IL-6
Nakanishi et al., Drug Metab Dispos 2011
(Hyperbilirubinemia) :
Fluorescence was negligible in SCHs from rat ( r ) Mrp2-deficient Eisai hyperbilirubinemic rat, suggesting that
Mrp2 is primarily
responsible for
CDF accumulation
Lee et al., Exp Mol Med 2013
(Arthritis, Rheumatoid) :
Upon
stimulation with
MRP8 ,
IL-6 production was enhanced by RA fibroblast-like synoviocytes ( FLS ) and was further elevated by coculturing RA FLS with activated CD4 ( + ) T cells ... Moreover, we demonstrated that
MRP8 activated
IL-6 production by RA FLS promoted differentiation of Th17 cells using the coculture system consisting of CD4 ( + ) T cells and RA FLS ... Inhibitor studies revealed that
MRP8 increased
IL-6 production in RA FLS via TLR4/phosphoinositide 3-kinase/nuclear factor-?B and mitogen activated protein kinase signaling pathways