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BCL6 — IL6

Text-mined interactions from Literome

Puthier et al., Br J Haematol 1999 (Multiple Myeloma) : In a system of apoptosis by growth factor deprivation on myeloma cells, we showed that the effect of Bcl-2 seemed minimal whereas Mcl-1 and Bcl-xL were tightly regulated by interleukin (IL)-6
Pu et al., Prostate 2004 (Prostatic Neoplasms) : Among Bcl-2 family proteins, only Bcl-xL was evidently increased by IL-6 stimulation
Nurieva et al., Science 2009 : Bcl6 expression is regulated by interleukin-6 and interleukin-21
Poholek et al., J Immunol 2010 : Bcl6 upregulation and T ( FH ) cell differentiation were independent of IL-6 and IL-21, revealing that either cytokine is not absolutely required for development of Bcl6 ( + ) T ( FH ) cells in vivo
Eto et al., PloS one 2011 : The combined absence of IL-6 and IL-21 resulted in reduced Tfh differentiation and reduced Bcl6 protein expression
Nakayamada et al., Immunity 2011 : Herein, we showed interleukin-12 acting via the transcription factor STAT4 induced both Il21 and Bcl6 genes, generating cells with features of both Tfh and Th1 cells
Kathiria et al., Cancer Res 2012 (Colitis...) : In wild-type p53 cells, PHB overexpression decreased basal and interleukin-6 induced STAT3 activation and expression of the STAT3 responsive genes Bcl-xL and Bcl-2
Choi et al., J Immunol 2013 : Cutting edge : STAT1 is required for IL-6 mediated Bcl6 induction for early follicular helper cell differentiation
Oritani et al., Blood 1999 : During this process, IL-6 downregulated expression of BCL2 in 1A9-M cells and stimulated BCL-XL expression, but had no effect on p53, Bax, or Bak gene expression