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CD28 — IL6

Text-mined interactions from Literome

Okkenhaug et al., Nat Immunol 2001 : Nonetheless, this mutated form of CD28 still prevents the induction of anergy and promotes T cell proliferation, interleukin 2 secretion and B cell help
Fournier et al., Clin Immunol 2002 (Acquired Immunodeficiency Syndrome) : Ex vivo secreting peripheral B cells had probably gone beyond the CD40/CD40 ligand interaction ; then following CD28/CD80 and CD27/CD27 ligand ( CD70 ) interactions in the presence of IL-6 , they achieved in vitro their differentiation into plasma cells
Orabona et al., Nat Immunol 2004 (Candidiasis...) : Here we show that mouse dendritic cells were induced by soluble CD28 to express interleukin 6 and interferon-gamma
Magari et al., Inflamm Res 2004 (Arthritis...) : LEF inhibited anti-CD3/CD28 induced production of TNF-alpha, IL-1beta and IL-6 , with IC50 values of 27, 21 and 21 microg/ml, respectively
Orabona et al., J Immunol 2005 : Although B7 engagement by either ligand leads to a mixed cytokine response, a dominant IL-6 production in response to CD28-Ig prevents the IFN-gamma-driven induction of immunosuppressive tryptophan catabolism mediated by IDO
Marin et al., Exp Hematol 2007 (Precursor Cell Lymphoblastic Leukemia-Lymphoma) : Moreover, the presence of 4-1BB or CD28 in the receptor increased the production of interleukin (IL)-2, tumor necrosis factor (TNF)-alpha, TNF-beta, IL-5, IL-6 , and IL-8 elicited by coculture with ALL cells
Abreu et al., Arthritis Res Ther 2010 (Arthritis, Experimental...) : Ex vivo, Rac1 inhibitory peptide suppressed T-cell receptor/CD28 dependent production of tumor necrosis factor alpha, interferon gamma and interleukin-17 by T cells from collagen primed mice, and reduced induction of ICOS and CD154, T-cell costimulatory proteins important for B-cell help
Dagur et al., J Autoimmun 2011 (Autoimmune Diseases...) : Upon TCR stimulation with CD3/CD28 , CD4 ( + ) CD146 ( + ) T cells secrete significantly more IL-17A, IL-6 , and IL-8 than do CD4 ( + ) CD146 ( - ) T cells
Lorré et al., Clin Immunol Immunopathol 1994 : Interleukin-1 and B7/CD28 interaction regulate interleukin-6 production by human T cells
Dumont et al., J Immunol 1998 : FK506 also reduced CD3/CD28 induced production of IL-3, IL-4, IL-10, TNF-alpha, and IL-6 but augmented that of GM-CSF, IL-5, IFN-gamma, and IL-13