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CD86 — IL6
Text-mined interactions from Literome
Blazevic et al., J Clin Immunol 2001
:
Inhibition studies using the B7-binding fusion protein CTLA4Ig and antibodies against CD80 and CD86 demonstrate that CTLA4Ig and
anti-CD86 inhibited influenza-specific T cell proliferation,
interleukin (IL)-2 and interferon (IFN)-gamma production, and generation of influenza-specific CD8+ CTL
Mainali et al., Cell Immunol 2004
:
However, Dx added during pre-DCs differentiation into immature DCs, prompted GcR translocation to the nucleus, enhanced DC apoptosis, suppressed differentiation to CD1a+ cells,
inhibited expression of
CD86 , reduced subsequent CD83 expression, maintained DC endocytic activity, suppressed
IL-6 secretion, enhanced IL-10 secretion, and reduced DC-mediated T cell stimulation
Herrmann et al., Infect Immun 2006
(Encephalomyelitis, Autoimmune, Experimental...) :
In contrast, the serum levels of tumor necrosis factor alpha and
interleukin-6 and spinal interleukin-6 levels were elevated, and the expression of major histocompatibility complex class II molecules, CD80, and
CD86 on splenic dendritic cells were
enhanced early after infection
Zhang et al., Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 2008
:
Chemical sensitizer DNCB could induce the high expression of
CD86 on DC membrane, and NiSO4 and HCA could
induce DC to release IL-1 beta and
IL-6
Rudnicka et al., Eur J Immunol 2009
(Arthritis, Rheumatoid) :
Stimulation of BM CD20 ( + ) B cells by CpG containing oligodeoxynucleotide enhanced expression of activation markers (
CD86 and CD54 )
triggered IL-6 and TNF-alpha secretion and cell proliferation