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DUSP1 — IL6

Text-mined interactions from Literome

Chen et al., J Immunol 2002 : Ectopic expression of MKP-1 accelerated JNK and p38 inactivation and substantially inhibited the production of TNF-alpha and IL-6
Quante et al., Am J Respir Cell Mol Biol 2008 : Moreover, TNF-alpha acts via a p38 MAPK dependent pathway to stabilize the IL-6 mRNA transcript ( TNF-alpha, t(1/2) = 9.6 h ; SB203580 + TNF-alpha, t(1/2) = 1.5 h ), exogenous expression of MKP-1 significantly inhibits TNF-alpha induced IL-6 secretion and MKP-1 siRNA reverses the inhibition of TNF-alpha induced IL-6 secretion by dexamethasone
Turpeinen et al., J Pharmacol Exp Ther 2010 : In the present study, we investigated the effect of MKP-1 on the expression of interleukin (IL)-6 , IL-8 and cyclooxygenase (COX)-2 in response to stimulation with cytokines ( tumor necrosis factor, IL-1beta, and interferon-gamma ; 10 ng/ml each ) in A549 human lung epithelial cells ... Down-regulation of MKP-1 with small interfering RNA enhanced p38 and JNK phosphorylation and increased IL-6 , IL-8, and COX-2 expression in A549 cells
Yu et al., Cytokine 2011 : In the current study, MKP-1 specifically dephosphorylated activated MAPK responses and attenuated LPS induced IL-6 , IL-10, and TNF-a expression
Kjellerup et al., Br J Dermatol 2013 (Dermatitis, Atopic...) : In NHEKs, interleukin (IL)-1ß induced DUSP1 mRNA expression in a rapid and time dependent manner through the p38 MAPK/mitogen- and stress activated kinase ( MSK ) signalling pathway