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IL6 — LEP

Text-mined interactions from Literome

Maruna et al., Vnitr Lek 2001 (Acute-Phase Reaction...) : Leptin mediates at least partly the anorectic effect of the tumour necrosis factor and interleukin 1 during inflammation
Gordeladze et al., J Cell Biochem 2002 : In terms of osteoclastic signaling, leptin significantly augmented the mRNA levels of both interleukin-6 (IL-6) and osteoprotegerin (OPG)
Bruun et al., Mol Cell Endocrinol 2002 : In contrast, IL-6 and IL-8 had no effect on either leptin production or leptin gene expression
Cameo et al., Biol Reprod 2003 : Effect of leptin on progesterone, human chorionic gonadotropin, and interleukin-6 secretion by human term trophoblast cells in culture ... In the present study, we investigated the role of leptin in the secretion of hCG, progesterone, and interleukin-6 (IL-6) by human term trophoblast cells in culture
Miller et al., Brain Behav Immun 2003 (Body Weight...) : Structural equation modeling yielded support for a model in which depressive symptoms promote weight accumulation, which in turn activates an inflammatory response through two distinct pathways : expanded adipose tissue release of interleukin-6 and leptin induced upregulation of interleukin-6 release by white blood cells ( CFI =.99 ; NNFI =.99 ; RMSEA =.05 )
Fukuda et al., Fertil Steril 2003 : The effects of leptin on the production of IL-6 , IL-11, leukemia inhibitory factor (LIF), IL-8, growth regulated oncogene ( GRO ) -alpha, monocyte chemoattractant protein (MCP)-1, and macrophage inflammatory protein (MIP)-3alpha by ESC and the endometrial epithelial cell line HHUA were investigated
Quinton et al., Am J Reprod Immunol 2003 : The effect of leptin on cell growth and on the production of cytokines [Leukaemia Inhibitory Factor (LIF), interleukin 6 and tumour necrosis factor-alpha ] and matrix metalloproteinases ( MMP ) ( MMP2 and MMP-9 ) was also investigated
Frisullo et al., J Clin Immunol 2004 (Multiple Sclerosis, Relapsing-Remitting) : Our data showed that leptin induced tumor necrosis factor-alpha, interleukin-6 , and interleukin-10 production by PBMCs of patients in an acute phase of disease but not in patients in a stable phase or in healthy controls
Trujillo et al., J Clin Endocrinol Metab 2004 : Interleukin-6 regulates human adipose tissue lipid metabolism and leptin production in vitro ... We used adipose tissue organ culture to test the direct effects of IL-6 on leptin expression, lipolysis, and lipoprotein lipase activity ... Although IL-6 had no significant effects under basal conditions, culture with the combination of IL-6 and dex, compared with dex alone, for 2 d increased leptin in both depots [ +95 +/- 30 % ( sc ) and +67 +/- 19 % ( Om ), P < 0.01 ] ; IL-6 did not affect leptin production when added in the presence of insulin
Stanley et al., J Bone Miner Res 2006 : We sought to determine whether osteoblasts (OBs) can serve as accessory cells (ACs) for T-cell activation and whether T cells directly activate OB production of IL-6 , using primary human OBs ( NHOst ), the transformed fetal osteoblast line hFOB1.19, and an osteosarcoma line SaOS-2
Fenton et al., Carcinogenesis 2006 (Obesity...) : Interleukin-6 production induced by leptin treatment promotes cell proliferation in an Apc ( Min/+ ) colon epithelial cell line ... Here we show, for the first time, that leptin induces elevated IL-6 production in IMCE cells but not in YAMC cells ... Further, we elucidate a novel mechanism by which leptin activates TACE/ADAM17 associated IL-6R shedding and trans-IL-6 signaling in IMCE by induction of IL-6 production ... These data implicate leptin induced IL-6 production, signaling and subsequent STAT3 activation as early events promoting the survival/proliferation of colon epithelial preneoplastic cells
Peeraully et al., Pflugers Arch 2006 : Prostaglandin D2 and J2-series ( PGJ2, Delta12-PGJ2 ) prostaglandins stimulate IL-6 and MCP-1, but inhibit leptin , expression and secretion by 3T3-L1 adipocytes
Flores et al., Diabetes 2006 : The regulatory role of interleukin (IL)-6 in mediating the increase in leptin and insulin sensitivity in hypothalamus was also investigated
Simons et al., J Endocrinol 2007 (Insulin Resistance) : Despite this reduction of lipid-laden adipocytes, TNF-alpha, IL-6/sIL-6R , and IL-1beta stimulated leptin release
Balasubramaniyan et al., Cytokine 2007 : The aim of our present work was to study the effect of exogenous leptin and/or ethanol on the secretion of TNF-alpha, IL-6 and TGF-beta1 both in vivo and in vitro
Tang et al., J Immunol 2007 : Leptin induced IL-6 production is mediated by leptin receptor, insulin receptor substrate-1, phosphatidylinositol 3-kinase, Akt, NF-kappaB, and p300 pathway in microglia ... Leptin caused concentration- and time dependent increases in IL-6 production ... Our results suggest that leptin increased IL-6 production in microglia via the leptin receptor/IRS-1/PI3K/Akt/NF-kappaB and p300 signaling pathway ... Leptin mediated IL-6 production was attenuated by OBRl receptor antisense oligonucleotide, PI3K inhibitor ( Ly294002 and wortmannin ), Akt inhibitor ( 1L-6-hydroxymethyl-chiro-inositol-2- ( ( R ) -2-O-methyl-3-O-octadecylcarbonate ) ), NF-kappaB inhibitor ( pyrrolidine dithiocarbamate ), IkappaB protease inhibitor ( L-1-tosylamido-2-phenylenylethyl chloromethyl ketone ), IkappaBalpha phosphorylation inhibitor ( Bay 117082 ), or NF-kappaB inhibitor peptide
Dube et al., Peptides 2008 (Body Weight...) : The elevated plasma CRP and IL-6 levels seen in obese ob/ob mice receiving the control vector, regardless of the fat content of the diet, were markedly suppressed by increased hypothalamic leptin in both groups
Fenton et al., Int J Cancer 2008 (Disease Models, Animal...) : Under serum-free conditions, adiponectin ( 1 mug/ml ) inhibited leptin induced autocrine IL-6 production, soluble IL-6 receptor shedding, trans-IL-6 signaling and subsequent STAT3 phosphorylation in IMCE cells ... These data indicate that adiponectin acts on preneoplastic colon epithelial cells to regulate cell growth via 2 distinct pathways inhibiting leptin induced NF-kappaB dependent autocrine IL-6 production and trans-IL-6 signaling
Maruna et al., Physiol Res 2009 (Hypertension, Pulmonary...) : Correlation between leptin and IL-6 indicates the role of IL-6 in leptin induction
Park et al., Joint Bone Spine 2009 (Spondylitis, Ankylosing) : Stimulation of PBMCs by exogenous leptin significantly increased the production of IL-6 and TNF-alpha in PBMCs from patients with AS in a dose dependent fashion and these increases were much exacerbated compared to controls
Vuolteenaho et al., Mediators Inflamm 2009 (Inflammation...) : Interestingly, inhibition of leptin induced NO production with a selective iNOS inhibitor 1400 W inhibited also the production of IL-6, IL-8, and PGE ( 2 ), and this was reversed by exogenously added NO-donor SNAP, suggesting that the effects of leptin on IL-6 , IL-8, and PGE ( 2 ) production are dependent on NO
Orlova et al., Bull Exp Biol Med 2009 : Leptin increased the expression of HLA-DR on T lymphocytes, stimulated the production of TNF-alpha and IL-6 , and did not affect secretion of IL-2, IL-4, and IL-10 by mononuclear leukocytes
Allman et al., Mediators Inflamm 2009 (Inflammation) : Compared to vehicle controls, leptin enhanced mRNA levels of IL-6 ( 8-fold ) and MCP-1 ( 5-fold ) in mesenteric adipose tissue ( MAT )
Ryan et al., Pflugers Arch 2010 : The PPARgamma agonist rosiglitazone stimulated both adiponectin and leptin expression and inhibited the expression of IL-6 , MCP-1 and TNFalpha ; MCP-1 secretion was reduced
Padidar et al., J Cell Physiol 2011 (Inflammation...) : IL6 , IL1ß and CXCL1 were up-regulated by leptin and localised to discrete cells in gut epithelium, lamina propria, muscularis and at the peritoneal serosal surface
Herrejón et al., Med Clin (Barc) 2011 (Body Weight...) : The IL-6 and TNF alpha levels were not modified in the MA group, but leptin did increase ( p < 0.043 )
Deng et al., J Trauma Acute Care Surg 2012 (MAP Kinase Signaling System...) : Here, we show that leptin reduced intestinal histologic alterations, malondialdehyde and interleukin-6 levels but increased the endogenous leptin expression and NO production in the intestines
Ponemone et al., Clinical and translational gastroenterology 2010 : APN, but not leptin , increased anti-CD3 induced IL-6 levels in LPL-T only in IBD patients
Zhang et al., J Infect Dis 2013 (Disease Models, Animal...) : Recombinant mouse leptin increased the interleukin 6 (IL-6) messenger RNA expression in mouse single-lung-cell preparations, mouse macrophages, and mouse lung epithelial cell lines infected with A ( H1N1 ) pdm09
Muraoka et al., Clin Exp Rheumatol 2013 (Arthritis, Rheumatoid) : Leptin stimulates interleukin-6 production via janus kinase 2/signal transducer and activator of transcription 3 in rheumatoid synovial fibroblasts ... Leptin induced production of IL-6 by RSFs was decreased after exposure to siRNA targeting leptin receptor ( Ob-Rb ) ... A JAK2 inhibitor, but not PI3K and MAPK inhibitors, decreased leptin induced IL-6 production
Granowitz et al., Biochem Biophys Res Commun 1997 (Inflammation) : When considered in the context of animal studies showing that interleukin-1 and tumor necrosis factor-alpha induce leptin and ob mRNA, these results suggest that pro-inflammatory cytokines induce ob gene transcription in vivo via secondary mediators such as transforming growth factor-beta
Faggioni et al., Am J Physiol 1998 (Inflammation) : To investigate the role of IL-1 beta and IL-6 in leptin expression during inflammation, we used IL-1 beta-deficient ( -/- ) and IL-6 -/- mice
Torpy et al., Horm Metab Res 1998 (Critical Illness...) : The negative relation between IL-6 and leptin is of potential importance, as high IL-6 levels have been associated with poor outcome in critically ill patients, and relatively low leptin levels may impair sympathetic system and immune functions