Neininger et al., J Biol Chem 2002
:
MK2 targets AU-rich elements and regulates biosynthesis of tumor necrosis factor and interleukin-6 independently at different post-transcriptional levels
Hegen et al., J Immunol 2006
(Arthritis, Experimental) :
We show that MK2 ( -/- ) and MK2 ( +/- ) mice exhibit decreased disease incidence and severity in the CIA disease model and reduced TNF-alpha and IL-6 serum levels following LPS/d-Gal treatment compared with wild-type mice
Clifton et al., FEBS Lett 1996
:
MAPKAP kinase-2 and MAPKAP kinase-3 were both activated in response to cellular stress, interleukin-1 and tumour necrosis factor in KB and HeLa cells, and with identical kinetics