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IL6 — SOD1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Ono et al., Biochem Biophys Res Commun 1992
(Carcinoma, Hepatocellular...) :
Induction of
Mn-superoxide dismutase by tumor necrosis factor,
interleukin-1 and interleukin-6 in human hepatoma cells ...
Effects of Tumor Necrosis Factor (TNF), Interleukin-1 (IL-1),
Interleukin-6 (IL-6) and Interferon-gamma (IFN-gamma) on the expression of
Mn-superoxide dismutase ( Mn-SOD ) protein were investigated in human hepatoma cells, Hu-H1, which revealed resistance to the cytotoxicity of TNF and IL-1
El-Assal et al., Cell Mol Immunol 2004
(Hepatitis, Alcoholic...) :
Finally,
IL-6 treatment
induces metallothionein protein expression, but not
superoxide dismutase and glutathione peroxidase in cultured hepatocytes
Tsan et al., Am J Physiol 1992
(Anoxia) :
However,
IL-6 markedly
enhances TNF-alpha- and IL-1 induced increases in Mn
SOD mRNA levels and O2 tolerance
Zi et al., Zhonghua Nan Ke Xue 2006
:
IL-6 could
induce the activity of acrosin and
superoxide dismutase ( SOD ) and enhance AR in human sperm
Nandi et al., Immunobiology 2010
(Endotoxemia) :
Current data also demonstrate the critical
role of
IL-6 in inducing
SOD in liver, whereas IL-6 prior and after LPS challenge group showed reduced PMN infiltration in the liver as evident by decreased hepatic MPO content in those mice
Jung et al., Stroke 2011
(Brain Ischemia...) :
This study demonstrates that IL-6 has a neuroprotective effect against cerebral ischemic injury through
IL-6R mediated STAT3 activation and
manganese-superoxide dismutase expression
Zhu et al., Nan Fang Yi Ke Da Xue Xue Bao 2012
(Acute Lung Injury) :
Compared with those in LPS group, IL-1ß,
IL-6 , TNF-a and MDA in BALF, W/D, lung injury scores and iNOS mRNA and protein expression were significantly reduced and
SOD in the BALF significantly
increased in LPS+DAS group
Fiala et al., American journal of neurodegenerative disease 2013
:
The inflammation is driven by
stimulation of macrophages by aggregated
superoxide dismutase 1 (SOD1) through caspase1, interleukin 1 (IL1),
IL6 and chemokine signaling
Masuda et al., FASEB J 1988
:
Induction of mitochondrial manganese
superoxide dismutase by
interleukin 1
Giełdanowski et al., Arch Immunol Ther Exp (Warsz) 1988
:
Studies on the
effect of
superoxide dismutase ( peroxinorm ) on
interleukin-1 activity
Kayanoki et al., J Biol Chem 1994
:
While interleukin-1 beta and
interleukin-6 induced
manganese-superoxide dismutase gene expression, they slightly suppressed catalase gene expression in rat hepatocytes
Niwa et al., Am J Pathol 1993
:
Both manganese
SOD and copper, zinc SOD activities were significantly
induced by paraquat,
interleukin-1 , tumor necrosis factor, adriamycin, and bleomycin in lymphocytes and neutrophils from asymptomatic non aged adults, whereas neither activity was induced in aged individuals