◀ Back to PTBP1
CASP7 — PTBP1
Pathways - manually collected, often from reviews:
-
BioCarta internal ribosome entry pathway:
Active caspases (CASP5/CASP3/CASP4/CASP8/CASP1/CASP7/CASP6/CASP2/CASP9/CASP10)
→
eIF-4G/eIF-4E/PTB complex (EIF4G1-EIF4G2-EIF4G3-EIF4E-PTBP1_PTBP2)
(modification, activates)
-
BioCarta internal ribosome entry pathway:
Active caspases (CASP5/CASP3/CASP4/CASP8/CASP1/CASP7/CASP6/CASP2/CASP9/CASP10)
→
c-Myc mRNA/eIF-4G (dimer)/eIF-3/eIF-4E/eIF-4A/PTB complex (EIF4A1-EIF4E-EIF3S10-EIF4G1-EIF4G2-EIF4G3-PTBP1_PTBP2)
(modification, activates)
Text-mined interactions from Literome
Zhang et al., Cell Death Differ 2009
:
PTB overexpression in cardiomyocytes
induced caspase activity and caspase dependent DNA fragmentation during ischemia, which is otherwise caspase independent in differentiated cardiomyocytes
Affaticati et al., Cell Death Differ 2011
(Calcium Signaling) :
Sustained calcium ( Ca ( 2+ ) ) signals and
caspase-3 activation in thymocytes were
induced by interaction with antigen pulsed
dendritic cells (DCs) and were inhibited by NMDAR antagonists MK801 and memantine
Ye et al., J Cell Sci 2013
:
HDAC5-deficient mice have reduced cardiac PTB protein abundance, and HDAC inhibition in myocytes causes a reduction in endogenous expression of cellular FLICE-like inhibitory protein ( cFLIP ) and
caspase dependent cleavage of
PTB