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ATM — ATR
Pathways - manually collected, often from reviews:
-
BioCarta role of brca1 brca2 and atr in cancer susceptibility:
ATR/ATRIP/ATM complex (ATR-TREX1-ATM)
→
BRCA2
(modification, activates)
-
BioCarta role of brca1 brca2 and atr in cancer susceptibility:
ATR/ATRIP/ATM complex (ATR-TREX1-ATM)
→
NBS1 (NBN)
(modification, activates)
-
BioCarta atm signaling pathway:
ATR/ATRIP/ATM complex (ATR-TREX1-ATM)
→
MDM2
(modification, activates)
-
BioCarta atm signaling pathway:
ATR/ATRIP/ATM complex (ATR-TREX1-ATM)
→
p53/MDM2 complex (TP53-MDM2)
(modification, activates)
-
BioCarta atm signaling pathway:
ATR/ATRIP/ATM complex (ATR-TREX1-ATM)
→
p53 (TP53)
(modification, activates)
-
BioCarta atm signaling pathway:
ATR/ATRIP/ATM complex (ATR-TREX1-ATM)
→
NF-kappa-B/I-kappa-B-alpha complex (NFKBIA-RELA)
(protein ubiquitination, activates)
-
BioCarta atm signaling pathway:
ATR/ATRIP/ATM complex (ATR-TREX1-ATM)
→
I-kappa-B-alpha/RELA/p50/ubiquitin complex (NFKBIA-RELA)
(protein ubiquitination, activates)
-
BioCarta atm signaling pathway:
ATR/ATRIP/ATM complex (ATR-TREX1-ATM)
→
RPA (RPA1)
(modification, activates)
-
BioCarta role of brca1 brca2 and atr in cancer susceptibility:
ATR/ATRIP/ATM complex (ATR-TREX1-ATM)
→
Hus1/Rad1/Rad9/Rad17 complex (HUS1-RAD1-RAD9A-RAD17)
(modification, activates)
-
BioCarta role of brca1 brca2 and atr in cancer susceptibility:
ATR/ATRIP/ATM complex (ATR-TREX1-ATM)
→
FA complex complex (FANCA-FANCC-FANCE-FANCF-FANCG)
(protein ubiquitination, activates)
-
BioCarta role of brca1 brca2 and atr in cancer susceptibility:
ATR/ATRIP/ATM complex (ATR-TREX1-ATM)
→
BRCA1
(protein ubiquitination, activates)
-
BioCarta role of brca1 brca2 and atr in cancer susceptibility:
ATR/ATRIP/ATM complex (ATR-TREX1-ATM)
→
FANCD2/ubiquitin complex (FANCD2)
(protein ubiquitination, activates)
-
BioCarta role of brca1 brca2 and atr in cancer susceptibility:
ATR/ATRIP/ATM complex (ATR-TREX1-ATM)
→
FANCD2
(protein ubiquitination, activates)
-
BioCarta role of brca1 brca2 and atr in cancer susceptibility:
ATR/ATRIP/ATM complex (ATR-TREX1-ATM)
→
BRCA1
(modification, activates)
-
BioCarta atm signaling pathway:
ATR/ATRIP/ATM complex (ATR-TREX1-ATM)
→
BRCA1/CTIP complex (BRCA1-RBBP8)
(modification, activates)
-
BioCarta atm signaling pathway:
ATR/ATRIP/ATM complex (ATR-TREX1-ATM)
→
BRCA1
(modification, activates)
-
BioCarta atm signaling pathway:
ATR/ATRIP/ATM complex (ATR-TREX1-ATM)
→
CTIP (RBBP8)
(modification, activates)
-
BioCarta regulation of cell cycle progression by plk3:
ATR/ATRIP/ATM complex (ATR-TREX1-ATM)
→
CHK1 (CHEK1)
(modification, activates)
-
BioCarta atm signaling pathway:
ATR/ATRIP/ATM complex (ATR-TREX1-ATM)
→
c-ABL (ABL1)
(modification, activates)
-
WikiPathways ATM Signaling Network in Development and Disease :
Complex of HMGN1-MDC1-ATM-MRE11A-RAD50-NBN
→
CDK5R1/RBBP8/CHEK2/RASGRF1/CHEK1/SMC1A/ATR/BUB1/CEP63/AURKB/CDK1/ATM/NBN/MRE11A/RAD50/ATM/ATM
(activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
ATR
—
ATM
(direct interaction, unspecified method)
Kim et al., J Biol Chem 1999
-
IRef Biogrid Interaction:
ATR
—
ATM
(direct interaction, enzymatic study)
Stiff et al., EMBO J 2006*
-
IRef Intact Interaction:
Complex of 11 proteins
(association, pull down)
Izumi et al., Science signaling 2010
-
IRef Intact Interaction:
Complex of ATR-RUVBL2-TTI2-MTOR-ATM-TELO2-PRKDC-TTI1
(association, tandem affinity purification)
Takai et al., Genes Dev 2010
-
IRef Intact Interaction:
Complex of ATM-TTI1-MTOR-ATR-PRKDC-SMG1
(association, anti tag coimmunoprecipitation)
Hurov et al., Genes Dev 2010
-
IRef Intact Interaction:
Complex of MTOR-ATM-TELO2-ATR-PRKDC-TRRAP
(association, anti bait coimmunoprecipitation)
Takai et al., Cell 2007
Text-mined interactions from Literome
Cerboni et al., Blood 2007
(Autolysis) :
In addition, T-cell activation stimulated phosphorylation of
ataxia-telangiectasia mutated (ATM) , a kinase required for NKG2DLs expression after DNA damage, and
ATM/Rad3 related kinase (ATR) inhibitors
blocked MICA induction on T cells with a mechanism involving NF-kappaB
Tomimatsu et al., EMBO Rep 2009
(Ataxia Telangiectasia) :
The cellular response to DNA double-strand breaks involves direct activation of
ataxia telangiectasia mutated (ATM) and indirect
activation of
ataxia telangiectasia and Rad3 related ( ATR ) in an ATM/Mre11/cell-cycle dependent manner