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CCNB1 — TP53
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Taylor et al., Mol Biol Cell 1999
:
Transcription of cdc2 and
cyclin B1 , determined using reporter constructs driven by the two promoters, was suppressed in
response to the induction of
p53
Park et al., Cancer Res 2000
:
Biochemical analysis showed that
p53 inhibits cell cycle dependent expression of cdc2 and
cyclin B1 and consequently inhibits cdc2 kinase
Taylor et al., J Biol Chem 2001
:
p53 represses the transcription of cdc2 and
cyclin B1 , causing loss of Cdc2 activity and G ( 2 ) arrest
Krause et al., Nucleic Acids Res 2000
:
Taken together with earlier observations on
p53 dependent transcription of
cyclin B1 , our results suggest that one way of regulating G ( 2 ) arrest may be a reduction in cyclin B levels through p53 dependent transcriptional repression
Dan et al., Biochem Biophys Res Commun 2001
(Lung Neoplasms) :
Previous reports have shown that overexpression of
p53 represses
cyclin B1 transcription
Taylor et al., Oncogene 2001
:
Binding of Cdc2 to Cyclin B1 is required for its activity, and
repression of the
cyclin B1 gene by
p53 also contributes to blocking entry into mitosis
Yin et al., Cancer Res 2001
:
Inverse
regulation of
cyclin B1 by c-Myc and
p53 and induction of tetraploidy by cyclin B1 overexpression
Li et al., Radiat Res 2002
:
The level of
cyclin B1 , required for CDC2 activity, was decreased in the
presence of functional
TP53
Yu et al., Mol Immunol 2002
(Neoplasms) :
We conclude that
p53 plays an important role in
cyclin B1 regulation and that tumors with mutated p53 will be good candidates for cyclin B1 based immunotherapy
Clifford et al., Cancer Res 2003
(Fibrosarcoma) :
We have previously found that the overexpression of
p53 causes G ( 2 ) arrest and
represses the synthesis of cyclin dependent kinase 1 and
cyclin B1 , two proteins required for cells to traverse from G ( 2 ) into M. G ( 2 ) arrest occurs in response to DNA damage caused by a variety of agents and treatments
Innocente et al., Biochem Biophys Res Commun 2005
:
We have previously reported that
p53 prevents G ( 2 ) /M transition by decreasing intracellular levels of both cyclin B1 mRNA and protein, and
attenuating the activity of the
cyclin B1 promoter
Ray et al., Cancer Res 2010
(Breast Neoplasms) :
Further studies revealed that BME treatment enhanced
p53 , p21, and pChk1/2 and
inhibited cyclin B1 and cyclin D1 expression, suggesting an additional mechanism involving cell cycle regulation
Nantajit et al., PloS one 2010
:
Herein, we reveal an anti-apoptotic role of mitochondrial
p53 regulated by the cell cycle complex
cyclin B1/Cdk1 in irradiated human colon cancer HCT116 cells with p53 ( +/+ ) status