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E2F5 — TP53

Text-mined interactions from Literome

Hale et al., J Biol Chem 1999 : Our studies indicate that E2F binding is not essential for activation of the p53 promoter but that ETF is
Bist et al., Biochemistry 2000 : Overexpression of E2F or p53 increased E2F binding to the -148 to -141 bp site, increased FC efflux, and inhibited cell division
James et al., Prog Cell Cycle Res 2000 : This provides a link between the Rb and p53 pathways and a mechanism whereby inactivation of Rb and release of E2F will lead to the stabilisation and functional activation of p53
Berkovich et al., Oncogene 2003 : This is accompanied by an E2F induced increase in p53 phosphorylation
Ramalho et al., J Neurochem 2004 : Notably, TUDCA modulated Abeta induced apoptosis, E2F-1 induction , p53 stabilization and Bax expression
Hershko et al., Cell Death Differ 2005 : However, it is not known how E2F directs p53 activity towards apoptosis rather than growth arrest
Fogal et al., EMBO J 2005 : This is the first demonstration that the activities of p53 are regulated during the cell cycle by E2F/p53 interactions and that phosphorylation of p53 at Ser315 is required for this regulation
Ruiz et al., Cell cycle (Georgetown, Tex.) 2006 (Carcinoma, Squamous Cell...) : In particular, we characterized the aberrant p53 activation mediated by E2F/p19(ARF) and other transduction pathways
Lara et al., Mol Carcinog 2007 (Carcinoma, Squamous Cell...) : Detailed biochemical analyses have indicated that, in the absence of pRb, multiple pathways, including the aberrant p53 activation mediated by E2F/p19(ARF) , are activated leading to increased tumor apoptosis
Danielian et al., Oncogene 2008 : E2f3 mutant mice typically die around birth and E2f3-deficient cells have a proliferation defect that correlates with impaired E2f target gene activation and also induction of p19(Arf) and p53
Zhang et al., J Cell Biochem 2010 : In turn, ARF may target E2F for its degradation via a p53 dependent mechanism
Lin et al., PloS one 2011 : H-eag1antisense antagonized the growth stimulating effects and the upregulation of h-eag1 expression in SHSY5Y cells, induced by knockdown of miR-34, E2F1 overexpression, or inhibition of p53 activity
Kanaan et al., Hum Mutat 2012 (Colitis, Ulcerative...) : Using two human colon cancer cell lines ( HT-29 and HCT-116 ), E2F1 , an upstream regulator of TP53 , was downregulated in both cell lines transfected with let-7e ( P < 0.05 ) as well as in HCT-116 cells transfected with miR-17 ( P < 0.05 )
Hiebert et al., Mol Cell Biol 1995 : In the absence of IL-3, E2F-1 alone was sufficient to induce apoptosis, and p53 levels were diminished
O'Connor et al., EMBO J 1995 : The expression of wild-type p53 can inhibit the transcriptional activity of E2F , and the expression of both E2F1 and DP1 can also downregulate p53 dependent transcription
Fan et al., Oncogene 1997 (Cell Transformation, Viral...) : In addition, in VA13 cells, induction of E2F97 resulted in down-regulation of the tumor suppressor protein p53