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MAPK4 — TP53

Text-mined interactions from Literome

Keller et al., Biochem Biophys Res Commun 1999 (Testicular Neoplasms) : Thus, these results suggest that UV-stimulated p53 phosphorylation at serine 389 is mediated by the stress-responsive p38MAPK
Lee et al., Proc Natl Acad Sci U S A 2000 : Furthermore, exposure of normal cells to DNA damaging agents induced MAPK activation in a p53 dependent manner ... Finally, activation of MAPK by p53 was inhibited by expression of dominant negative Ras ( N17Ras ) and Raf1 mutants, indicating that MAPK activation by p53 is mediated at a level upstream of Ras
Shih et al., Biochemistry 2001 (MAP Kinase Signaling System) : T ( 4 ) also caused nuclear co-immunoprecipitation of TRbeta1 and p53, an effect also inhibited by PD. Nuclear complexing of p53 and MAPK also occurred in HeLa cells, which lack functional TR. Constitutively activated MAPK caused phosphorylation of a recombinant p53-GST fusion protein in vitro ; thus, p53 is a substrate for MAPK
Fang et al., EMBO J 2001 (MAP Kinase Signaling System) : HB-EGF neutralizing antibody and inhibitors of EGF receptor signaling abrogated p53 induced MAPK activation ... Additionally, the PI3K/Akt pathway was activated in response to p53 signaling through HB-EGF induction, and inhibition of MAPK and Akt activation after DNA damage decreased cell survival in wild-type p53 containing cells
Kwon et al., J Biol Chem 2002 : MC induced p38 MAPK activation in p53 expressing cells but not in p53-deficient cells, indicating that the p38 MAPK activation was dependent on early p53 activation
Kaji et al., Nitric Oxide 2002 : Western blot analysis indicated that p53 accumulation caused by SIN-1 did not require p53 phosphorylation, whereas SIN-1 treatment triggered MAP kinase ( MAPK ) phosphorylation and pretreatment with the MAP kinase kinase ( MEK ) inhibitor U0126 inhibited p53 accumulation
Bulavin et al., Mol Cell Biol 2003 (MAP Kinase Signaling System) : Inhibition of p38 mitogen activated protein kinase ( MAPK ) activation correlated with the deregulation of p53 activation, and both a p38 MAPK chemical inhibitor and the expression of a dominant negative p38alpha inhibited p53 activation in the presence of H-ras in wild-type MEF
Wang et al., Biochem Biophys Res Commun 2004 (Colorectal Neoplasms) : Using isogenic colon cancer cell lines and RNA interference, we show that loss of p53 significantly reduces MAPK phosphorylation and renders cells resistant to U0126 treatment
Menendez et al., Oncogene 2005 (Breast Neoplasms...) : Strikingly, CYR61 overexpression impaired the accumulation of wild-type p53 following Taxol exposure, while inhibition of alphavbeta3 or ERK1/ERK2 MAPK signalings completely restored Taxol induced upregulation of p53
Perfettini et al., J Exp Med 2005 (HIV Infections) : Inhibition of p38 MAPK by pharmacological inhibitors, dominant negative p38, or small interfering RNA, suppressed p53S46P ( but not p53S15P ), the expression of p53-inducible genes, the conformational activation of proapoptotic Bax and Bak, the release of cytochrome c from mitochondria, and consequent apoptosis
Menendez et al., Int J Cancer 2005 (Breast Neoplasms) : Co-exposure to C75 and Taxol induced a remarkable nuclear accumulation of activated p38 mitogen activated protein kinase ( p38 MAPK ), which was accompanied by a synergistic nuclear accumulation of the p53 tumor-suppressor protein that was phosphorylated at Ser46, a p38 MAPK regulated pro-apoptotic modification of p53
Nuntharatanapong et al., Am J Physiol Heart Circ Physiol 2005 : Moreover, inhibition of JNK with SP-600125 or dominant negative MKK7 inhibited only p21Cip1/Waf1 induction, whereas the p38 MAPK inhibitor SB-203580 or dominant negative MKK4 inhibited both p21Cip1/Waf1 and p53 induction
Mukherjee et al., Carcinogenesis 2006 (Chromosomal Instability) : Activation of both ERKs and p38 MAPK by BPDE and attenuation of BPDE induced p53 accumulation by U0126 or SB202190, specific inhibitor of MEK1/2 or p38 MAPK, indicate the role of ERKs and p38 MAPK in p53 accumulation
Jackson et al., J Biol Chem 2006 (MAP Kinase Signaling System) : Inhibition of p38 MAPK or MEK via pharmacological means or expression of dominant negative proteins inhibited the cytoplasmic accumulation of Hdm2 and increased Hdm2 and p53 protein levels, whereas constitutively active p90Rsk promoted the nuclear export of Hdm2
Tang et al., Mol Cancer Ther 2006 (Breast Neoplasms) : The interaction of COX-2, p53 , and p300, as well as resveratrol induced apoptosis, was inhibited by a MAPK activation inhibitor, PD98059
Cordenonsi et al., Science 2007 : We find that RTK/Ras/MAPK ( mitogen activated protein kinase ) activity induces p53 N-terminal phosphorylation, enabling the interaction of p53 with the TGF-beta activated Smads
Bragado et al., Apoptosis 2007 : p38alpha MAPK contributes to further activation of p53 , which leads to a positive feedback loop, p38alpha MAPK/p53
Nold et al., Thromb Haemost 2007 (Disease Models, Animal...) : Furthermore, we showed that the regulation of the pro-apoptotic cell cycle regulator p53 by PC and aPC is dependent on the reduction of p38MAPK activation
Lin et al., Toxicology 2008 : MAPK regulate p53 dependent cell death induced by benzo [ a ] pyrene : involvement of p53 phosphorylation and acetylation
Toit-Kohn et al., J Nutr Biochem 2009 (Adenocarcinoma...) : Furthermore, siRNA experiments suggested a possible role for p38 MAPK in the phosphorylation of p53 at Ser15, a site which is associated with DNA damage
Lecona et al., Mol Cell Biol 2008 (Adenocarcinoma...) : Upregulation of annexin A1 expression by butyrate in human colon adenocarcinoma cells : role of p53 , NF-Y, and p38 mitogen activated protein kinase ... The interaction of p53 with the promoter is dependent on p38 MAPK activity either in the absence or in the presence of butyrate
Rasmussen et al., Inflamm Res 2008 (Inflammation) : Using three MAPK inhibitors we showed that p38 MAPK and JNK dependent mechanisms are involved in the regulation of the IL-8 and p53 protein expression
Zdanov et al., Biogerontology 2009 : In this work, p38 ( MAPK ) activation and increased DNA binding activities of ATF-2 and p53 are shown to mediate cyclooxygenase-2 overexpression in premature senescence
Lin et al., Virology 2009 : Modulation of p53 by mitogen activated protein kinase pathways and protein kinase C delta during avian reovirus S1133 induced apoptosis
Piccirillo et al., J Biol Chem 2009 (Adenocarcinoma) : We show that p53 is activated in response to diamide treatment by the oxidative induction of the Trx1/p38 ( MAPK ) signaling pathway
Kim et al., Ann N Y Acad Sci 2009 (MAP Kinase Signaling System) : Phloretin induces apoptosis in H-Ras MCF10A human breast tumor cells through the activation of p53 via JNK and p38 mitogen activated protein kinase signaling
Roobol et al., Biochem J 2011 (Hypothermia) : In addition, we show that although p38MAPK ( p38 mitogen activated protein kinase ) is also involved in activation of p53 upon mild hypothermia, this is probably the result of activation of p38MAPK by ATR
Kim et al., The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2010 : Together, these results suggest that p53 dependent induction of JNK/p38 MAPK directly participates in apoptosis induced by melatonin
Saha et al., Oncogene 2012 (Uterine Cervical Neoplasms) : Functional restoration of p53 can be achieved by non-steroidal anti-inflammatory drug celecoxib via multiple molecular mechanisms : ( i ) inhibition of p53 degradation by suppressing viral oncoprotein E6 expression, ( ii ) promoting p53 transcription by downmodulating cycloxygenase-2 (Cox-2) and simultaneously retrieving p53 from Cox-2 association and ( iii ) activation of p53 via ataxia telangiectasia mutated-/p38 mitogen activated protein kinase mediated phosphorylations at serine-15/-46 residues
George et al., PloS one 2011 (Cell Transformation, Neoplastic...) : Mechanistic studies revealed that this combinatorial inhibition was associated with decreased expression of phosphorylated mitogen activated protein kinase family proteins : extracellular signal regulated kinase 1/2, c-Jun N-terminal kinase 1/2, p38 and increased in total p53 and phospho p53 ( Ser 15 ) in skin tissue/tumor
Allen et al., Mol Cancer Ther 2012 (Colorectal Neoplasms) : Thus, in the absence of wild-type p53 , SN38 promotes migration of colorectal cancer cells, and inhibiting MAPK blocks this potentially prometastatic adaptive response to this anticancer drug
Furlan et al., J Hepatol 2012 : We investigated the mechanism leading to p53 regulation by Met and found that Abl and p38MAPK are required for p53 phosphorylation on S ( 389 ), Mdm2 upregulation, and hepatocyte survival
Yang et al., Phytother Res 2013 : The expression of p53 and its downstream genes p21 ( WAF1 ) and Bax were enhanced by blocking the activation of p42/p44 MAPK in response to treatment with vitexin
Wu et al., Radiology and oncology 2013 : The inhibition of p38 MAPK activation by SB203580 or siRNA reduced Eag protein level but increased p53 protein level
Lin et al., Genes Dev 1998 (Cell Transformation, Neoplastic) : Consequently, constitutive MAPK signaling activates p53 and p16 as tumor suppressors