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NPEPPS — TP53
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Gurova et al., Oncogene 2002
(Adenocarcinoma...) :
Expression of
prostate specific antigen (PSA) is negatively
regulated by
p53 ... Consistently,
p53 suppression
caused a 4-8-fold increase in secretion of
PSA protein in culture medium, suggesting that PSA gene expression is under negative control of p53 ... While wild type p53 strongly repressed, dominant negative
p53 mutants
stimulated PSA promoter-driven transcription and secretion of
PSA in transient transfection experiments
Tsui et al., J Urol 2004
:
We identified the mechanisms responsible for the
effect of
p53 on
prostate specific antigen (PSA) expression by prostate cancer cell lines in vitro and investigated the role of a putative p53 response element in the PSA promoter region in prostate cancer cells ... Results demonstrate that
p53 regulates
PSA gene expression through a putative p53 response element in the PSA promoter within human prostate cancer cells