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RPS2 — TP53

Text-mined interactions from Literome

Yuan et al., Mol Cell 2005 (Cell Transformation, Viral) : Elevated levels of p53 after TIF-IA depletion are due to increased binding of ribosomal proteins , such as L11, to MDM2 and decreased interaction of MDM2 with p53 and p19(ARF)
Zhang et al., J Biol Chem 2006 : Interaction with ribosomal proteins results in inhibition of Hdm2 mediated ubiquitination and degradation of p53
Lindström et al., Cell cycle (Georgetown, Tex.) 2007 (Neoplasms) : Following nucleolar stress, ribosomal proteins L5, L11 and L23 bind to MDM2, blocking MDM2 mediated p53 ubiquitination and degradation
Dai et al., Cell cycle (Georgetown, Tex.) 2007 : Several ribosomal proteins including L11 have been shown to activate p53 by inhibiting oncoprotein MDM2, leading to inhibition of cell cycle progression
Ma et al., Trends Cell Biol 2008 : A recent study has demonstrated that loss of NS promotes the interaction of L5 and L11 ribosomal proteins with MDM2 and, thus, also prevents p53 degradation
Zhang et al., Cancer Cell 2009 : In response to this stress, several ribosomal proteins bind to MDM2 and block MDM2 mediated p53 ubiquitination and degradation, resulting in p53 dependent cell cycle arrest
Sun et al., J Biol Chem 2011 : Several ribosomal proteins have been shown to induce and activate p53 via inhibition of MDM2
Suzuki et al., Cancer Sci 2012 (Neoplasms) : For example, how do RPs translocate from the nucleolus to the nucleoplasm to exert their functions, and do these p53 regulating RPs influence the prognosis of human cancer patients ?
Xiong et al., Journal of the American Heart Association 2013 : The activation of p66Shc but not p53 by Arg-II was dependent on extracellular signal regulated kinases ( ERKs ) and sequential activation of 40S ribosomal protein S6 kinase 1 (S6K1)-c-Jun N-terminal kinases (JNKs)