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TP53 — WT1

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: WT1 — TP53 (direct interaction, pull down) Johnstone et al., J Biol Chem 1998*
• IRef Biogrid Interaction: WT1 — TP53 (physical association, affinity chromatography technology) Maheswaran et al., Proc Natl Acad Sci U S A 1993*
• IRef Hprd Interaction: TP53 — WT1 (in vivo) Scharnhorst et al., J Biol Chem 2000*, Maheswaran et al., Proc Natl Acad Sci U S A 1993*
• IRef Ophid Interaction: WT1 — TP53 (aggregation, confirmational text mining) Maheswaran et al., Proc Natl Acad Sci U S A 1993*
• IRef Ophid Interaction: WT1 — TP53 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Maheswaran et al., Genes Dev 1995 (Wilms Tumor) : The WT1 gene product stabilizes p53 and inhibits p53 mediated apoptosis ... Expression of WT1 resulted in increased steady-state levels of p53 , attributable to a prolongation in protein half-life, and associated with protection against papillomavirus E6-mediated degradation of p53
Maheswaran et al., Proc Natl Acad Sci U S A 1993 (Kidney Neoplasms...) : In the absence of p53 , WT1 acts as a potent transcriptional activator of the early growth response gene 1 (EGR1) site, rather than a transcriptional repressor