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UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining

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CD40LG — VEGFA

Text-mined interactions from Literome

Cho et al., J Immunol 2000 (Arthritis, Rheumatoid) : The CD40L on activated T cells from rheumatoid synovial fluid also up-regulated VEGF production from FLS ... Neither indomethacin nor Abs to IL-1beta, TNF-alpha, and TGF-beta did affect CD40L induced VEGF production ... Dexamethasone completely abrogated CD40L induced VEGF production ... In addition, pyrrolidine dithiocarbamate partially down-regulated CD40L induced VEGF production, showing that the NF-kappaB pathway was partly involved in the signaling of CD40L leading to VEGF production
Kiriakidis et al., J Cell Sci 2003 (Inflammation...) : In addition, we observed significant inhibition of the CD40L induced VEGF production in macrophages following infection with AdvIkappaBalpha ... Expression of IKK-2dn in macrophages decreased VEGF production in response to LPS or CD40L by approximately 50 %, suggesting that in addition to IKK-2, other kinases might be involved in NF-kappaB activation
Farahani et al., Leukemia 2005 (Leukemia, Lymphocytic, Chronic, B-Cell) : Autocrine VEGF mediates the antiapoptotic effect of CD154 on CLL cells ... We report for the first time that treatment of CLL cells with CD154 results in increased VEGF production and demonstrate involvement of NF-kappaB in this process
Futagami et al., Prostaglandins Leukot Essent Fatty Acids 2008 (Stomach Neoplasms) : The aim of this study was to examine the effect of MCP-1/CCR2 and CD40-CD40L interaction on COX-2 and VEGF expression in endothelial cells ... CD40L stimulated VEGF production was COX-2 but not COX-1 dependent
Furukawa et al., Fertil Steril 2009 : Following stimulation by thrombin and TRP-6, the production of VEGF, MMP-1, and active MMP-2 statistically significantly increased ; U0126 and PPACK statistically significantly suppressed the increases in the production of VEGF , MMP-1, and active MMP-2 induced by thrombin and TRAP-6
Futagami et al., J Gastroenterol 2008 (Adenocarcinoma...) : MCP-1 and CD40L had a synergistic effect on COX-2 expression and subsequent VEGF production in gastric cancer