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MYLIP — VEGFA

Text-mined interactions from Literome

Suárez et al., Proc Natl Acad Sci U S A 2008 : Furthermore, VEGF regulated the expression of several miRNAs, including the up-regulation of components of the c-Myc oncogenic cluster miR-17-92
Wu et al., Cell Res 2009 (Breast Neoplasms...) : Finally, western blot combined with the luciferase reporter assays demonstrate that ErbB3 and vascular endothelial growth factor A ( VEGF-A ) are direct targets for miR-205 , and this miR-205 mediated suppression is likely through the direct interaction with the putative miR-205 binding site in the 3'-untranslated region ( 3'-UTR ) of ErbB3 and VEGF-A
Lei et al., PloS one 2009 (Anoxia...) : The inhibition of miR-20b increased the protein levels of HIF-1alpha and VEGF in normoxic tumor cells ; the increase of miR-20b in hypoxic tumor cells, nevertheless, decreased the protein levels of HIF-1alpha and VEGF ... Thus, we identify a novel molecular regulation mechanism through which miR-20b regulates HIF-1alpha and VEGF and is regulated by HIF-1alpha so to keep tumor cells adapting to different oxygen concentrations
Kushibiki et al., J Biophotonics 2010 : Since miR-210 is the most prominent miRNA consistently stimulated under hypoxic conditions and VEGF is capable of increasing miR-296 expression levels, these data suggest that hypoxia induced by PDT induces miR-210 expression, followed by an increase of VEGF expression and miR-296 expression
Cascio et al., J Cell Physiol 2010 (Breast Neoplasms) : We investigated whether and how miR-20b can regulate the expression of vascular endothelial growth factor ( VEGF ) in MCF-7 breast cancer cells under normoxic and hypoxia mimicking conditions ( CoCl ( 2 ) exposure ) ... In addition, miR-20b reduced VEGF protein expression in untreated cells ... Next, we investigated the molecular mechanism by which pre-miR-20b can affect VEGF transcription, focusing on hypoxia inducible factor 1 (HIF-1) and signal transducer and activator of transcription 3 ( STAT3 ), transcriptional inducers of VEGF and putative targets of miR-20b ... In summary, this report demonstrates, for the first time, that the VEGF expression in breast cancer cells is mediated by HIF-1 and STAT3 in a miR-20b dependent manner
Yamakuchi et al., Proc Natl Acad Sci U S A 2010 (Neoplasms...) : Furthermore, overexpression of miR-107 in tumor cells suppresses tumor angiogenesis, tumor growth, and tumor VEGF expression in mice
Long et al., J Biol Chem 2010 (Diabetes Mellitus...) : Here, we provide evidence that microRNA-93 (miR-93) regulates VEGF expression in experimental models of diabetes both in vitro and in vivo ... Conversely, anti-miR-93 inhibitors increased VEGF release ... Transfection of miR-93 also prevented the effect of high glucose on VEGF downstream targets
Smits et al., PloS one 2011 : Here we show that VEGF mediated down-regulation of miR-101 caused pro-angiogenic effects
Liu et al., PloS one 2011 (Neovascularization, Pathologic) : We found that overexpression of miR-21 in DU145 cells increased the expression of HIF-1a and VEGF , and induced tumor angiogenesis
Dejean et al., Leukemia 2011 (Anoxia...) : Second, we found that modification of miR-16 levels in TPM3-ALK MEF cells greatly affected VEGF levels ... Third, we demonstrated that miR-16 directly interacts with VEGF mRNA at the 3'-untranslated region and that the regulation of VEGF by miR-16 occurs at the translational level
Chamorro-Jorganes et al., Arterioscler Thromb Vasc Biol 2011 : This upregulation was accompanied by a parallel increase in primary transcript ( pri-miR ) -16-1 and pri-miR-16-2 but not in pri-miR-424 levels, indicating a VEGF/bFGF dependent transcriptional and posttranscriptional regulation of miR-16 and miR-424 , respectively
Liu et al., Kidney Blood Press Res 2012 (Neovascularization, Pathologic...) : Furthermore, overexpression of miR-210 in HUVEC-12 cells enhances VEGF and VEGFR2 expression and promotes angiogenesis on Matrigel in vitro
Alaiti et al., J Cell Mol Med 2012 : Up-regulation of miR-210 by vascular endothelial growth factor in ex vivo expanded CD34+ cells enhances cell mediated angiogenesis
Muramatsu et al., Oncogene 2013 (Anoxia...) : Here, we show that miR-125b expression is transiently induced in ECs on stimulation with vascular endothelial growth factor or by ischemia
Li et al., Arthritis Res Ther 2012 (Osteoarthritis) : miR-146a , an IL-1ß responsive miRNA, induces vascular endothelial growth factor and chondrocyte apoptosis by targeting Smad4
Kobus et al., Liver Int 2012 : To explore the involvement of flow sensitive lung Kruppel-like factor ( KLF2 ), microRNA-126 (miR-126) , angiopoietin-2 (Ang-2) and heme oxygenase-1 (HO-1) in modulation of vascular endothelial growth factor ( VEGF ) signalling that have a critical effect on growth of new blood vessels ... The expression of miR-126 , a KLF2 mediated regulator of the VEGF signalling was enhanced in cirrhotic patients
Pin et al., Angiogenesis 2012 : Thereafter, we found that miR-20a expression is increased by VEGF and that its ectopic expression inhibits VEGF induced actin remodeling and cell migration
Bi et al., PloS one 2012 (Carcinoma, Hepatocellular...) : Inhibiting miR-125a could increase both MMP11 and VEGF-A expression, and RNA interference targeting MMP11 or VEGF-A mRNA could rescue the loss of miR-125a functions
Pin et al., J Biol Chem 2012 : Interestingly, VEGF reduces the expression of miR-196a , which is associated with an increased level of ANXA1 ... We conclude that the VEGF induced decrease of miR-196a expression may participate to the angiogenic switch by maintaining the expression of ANXA1 to levels required to enable p38-ANXA1 dependent endothelial cell migration and angiogenesis in response to VEGF
Afonyushkin et al., Atherosclerosis 2012 : Permissive role of miR-663 in induction of VEGF and activation of the ATF4 branch of unfolded protein response in endothelial cells by oxidized phospholipids
Sasahira et al., Br J Cancer 2012 (Carcinoma, Squamous Cell...) : MicroRNA-126 (miR-126) was associated with cell growth and regulation of vascular endothelial growth factor-A activity, and demethylation treatment increased expression levels of miR-126 and EGFL7 in OSCC cells
Feng et al., ISRN endocrinology 2012 : Data from this study indicates that miR-320 negatively regulates expression of ET-1, VEGF , and FN through ERK 1/2
Bao et al., PloS one 2012 (Neoplasm Invasiveness...) : The treatment of PCa cells with CDF, a novel Curcumin derived synthetic analogue previously showed anti-tumor activity in vivo, inhibited the productions of VEGF and IL-6, and down-regulated the expression of Nanog, Oct4, EZH2 mRNAs, as well as miR-21 under hypoxic condition
Dal Monte et al., Naunyn Schmiedebergs Arch Pharmacol 2013 (Neovascularization, Pathologic) : miR-361 overexpression reduced hypoxia induced cell proliferation and VEGF release indicating miR-361 involvement in the acquisition of an angiogenic phenotype by HUVEC
Stahlhut et al., Development 2012 : Using target protectors, our results indicate that miR-1/206 directly regulate the levels of Vascular endothelial growth factor A ( VegfA ) in muscle, controlling the strength of angiogenic signaling to the endothelium
Yin et al., Biochim Biophys Acta 2013 (Cell Transformation, Neoplastic...) : To understand the potential mechanism of miR-145 in inhibiting tumor growth, we showed that miR-145 blocked the activation of AKT and ERK1/2 pathways, and the expression of HIF-1 and VEGF via directly targeting N-RAS and IRS1, and VEGF is an important effector for tumor growth
Deng et al., Gene 2013 (Stomach Neoplasms) : Expression of cyclin dependent kinase 6 and vascular endothelial growth factor was down-regulated by exogenous miR-195 and miR-378, respectively
Wang et al., Hepatology 2013 (Carcinoma, Hepatocellular...) : Subsequent investigations disclosed that miR-195 directly inhibited the expression of the proangiogenic factor vascular endothelial growth factor ( VEGF ) and the prometastatic factors VAV2 and CDC42 ... Furthermore, we revealed that miR-195 down-regulation resulted in enhanced VEGF levels in the tumor microenvironment, which subsequently activated VEGF receptor 2 signaling in endothelial cells and thereby promoted angiogenesis
Noguchi et al., Mol Ther 2013 (Melanoma) : Exogenous miR-205BP/S3 suppressed the protein expression levels of E2F1 and VEGF , which are validated targets of miR-205-5p, and BCL2, a transcribed molecule of E2F1, as did Pre-miR-205, used as a miR-205 mimic having the wild-type sequence
Zhang et al., Oncol Rep 2013 : In conclusion, our findings suggest that DNA methylation induced silencing of miR-126 contributes, at least in part, to tumor invasion and angiogenesis in CRC, through upregulation of VEGF expression
Yang et al., PloS one 2013 : Our results confirmed that VEGFA is a direct target of these miRNAs, as both miR-29a , c and miR-203 strongly and specifically suppressed endogenous VEGFA expression in vitro