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NOX4 — VEGFA

Text-mined interactions from Literome

Brandes et al., Antioxid Redox Signal 2003 : By influencing the activity of p38 mitogen activated protein kinase and AKT, NADPH oxidase derived O ( 2 ) .- increases the expression of several pro-arteriosclerotic genes, such as monocyte chemoattractant protein-1, tissue factor, and vascular endothelial growth factor
Ikeda et al., Circ Res 2005 (Ischemia) : We have shown that VEGF stimulates a Rac1 dependent NAD ( P ) H oxidase to produce reactive oxygen species ( ROS ) that are involved in VEGFR2 autophosphorylation and angiogenic related responses in ECs
Mata-Greenwood et al., Am J Physiol Lung Cell Mol Physiol 2005 : Cyclic stretch increases VEGF expression in pulmonary arterial smooth muscle cells via TGF-beta1 and reactive oxygen species : a requirement for NAD ( P ) H oxidase
Al-Shabrawey et al., Am J Pathol 2005 (Anoxia...) : Inhibition of NAD ( P ) H oxidase activity blocks vascular endothelial growth factor overexpression and neovascularization during ischemic retinopathy ... Because oxidative stress has been strongly implicated in up-regulation of vascular endothelial growth factor ( VEGF ) expression in ischemic retinopathy, we evaluated the role of NAD ( P ) H oxidase in causing VEGF overexpression and retinal neovascularization ... Apocynin and gp91ds-tat also blocked the action of hypoxia in causing increased VEGF expression in vitro, confirming the specific role of NAD ( P ) H oxidase in hypoxia induced increases in VEGF expression ... In conclusion, NAD ( P ) H oxidase activity is required for hypoxia stimulated increases in VEGF expression and retinal neovascularization
Ikeda et al., Arterioscler Thromb Vasc Biol 2005 (Vascular Diseases) : We reported that IQGAP1, an actin binding scaffold protein, mediates VEGF induced activation of gp91phox ( Nox2 ) -dependent NAD ( P ) H oxidase and EC migration
Yamagishi et al., J Biol Chem 2006 (Diabetic Retinopathy) : These results indicate that the central mechanism for PEDF inhibition of the AGE signaling to vascular permeability is by suppression of NADPH oxidase mediated ROS generation and subsequent VEGF expression
Li et al., Metabolism 2006 (Diabetic Retinopathy) : In the present study, we investigated the role of nicotinamide adenine dinucleotide phosphate ( reduced form ) ( NADPH ) oxidase in AGE induced ROS intracellular generation and vascular endothelial growth factor ( VEGF ) expression in bovine retinal endothelial cells ( BRECs ) ... Overall, these results demonstrate that AGEs induce intracellular ROS generation and VEGF expression in retinal endothelial cells through a PKC dependent activation of NADPH oxidase
Black et al., Conf Proc IEEE Eng Med Biol Soc 2004 : Cyclic stretch increases VEGF expression in pulmonary arterial smooth muscle cells via TGF-1 and reactive oxygen species : a requirement for NAD ( P ) H oxidase
Abid et al., J Biol Chem 2007 : We show that NADPH oxidase activity is required for VEGF activation of phosphoinositide 3-kinase-Akt-forkhead, and p38 MAPK, but not ERK1/2 or JNK
Xu et al., Free Radic Biol Med 2008 : VEGF induced Nox4 upregulation was associated with an enhanced proliferation and angiogenesis of HUVEC
Vural et al., Int Immunopharmacol 2009 (Hashimoto Disease) : Plasma TGF-beta1 and VEGF were decreased, and NOx increased in HT patients in comparison with controls
Li et al., Diabetes 2010 : Overexpression of Nox4 increased basal level of ROS generation, HIF-1alpha, and VEGF expression in RCECs ... Activation of Nox4 plays an important role in high-glucose- and hypoxia mediated VEGF expression and diabetes induced BRB breakdown
Feng et al., Arterioscler Thromb Vasc Biol 2010 : Endothelium dependent vascular endothelial growth factor regulation of coronary vascular tone may require NADPH oxidase derived ROS to activate phosphatidylinositol 3-kinase-Akt-endothelial NO synthase axis
Monaghan-Benson et al., Am J Pathol 2010 (Choroidal Neovascularization...) : The role of vascular endothelial growth factor induced activation of NADPH oxidase in choroidal endothelial cells and choroidal neovascularization ... We found that vascular endothelial growth factor induced the activation of Rac1 and of NADPH oxidase in cultured human choroidal endothelial cells
Meng et al., PloS one 2012 : NADPH oxidase 4 mediates insulin stimulated HIF-1a and VEGF expression, and angiogenesis in vitro ... In this study we examined the role of NADPH oxidase subunit 4 (Nox4) in insulin stimulated HIF-1a and VEGF expression, and angiogenic responses in human microvascular endothelial cells ( HMVECs ) ... Inhibition of Nox4 expression inhibited the transcriptional activity of VEGF through HIF-1 ... Overexpression of wild-type Nox4 was sufficient to increase VEGF transcriptional activity, and further enhanced insulin stimulated the activation of VEGF ... Inhibition of Nox4 impaired insulin stimulated VEGF expression, cell migration, cell proliferation, and tube formation in HMVECs