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SMAD4 — VEGFA

Text-mined interactions from Literome

Nakagawa et al., American journal of physiology. Renal physiology 2004 (Anoxia) : Rat proximal tubular ( NRK52E ) cells treated with TGF-beta under normoxic conditions secreted VEGF at 24 h, and this was significantly reduced by blocking Smad activation by overexpressing the inhibitory Smad7 or by blocking p38 and ERK1/2 MAP kinase activation or protein kinase C activation with specific inhibitors
Chen et al., BMB Rep 2010 (Carcinoma...) : The stable expression of Smad4 increased the expression of E-cadherin, reduced the expression of plasminogen activator inhibitor-1 ( PAI-1 ) and slightly down-regulated the expression of VEGF
Papageorgis et al., Cancer Res 2011 (Cell Transformation, Neoplastic...) : We found that loss of function of Smad4 and retention of intact TGFß receptors could synergistically increase the levels of VEGF , a major proangiogenic factor
Huang et al., Mol Med Report 2010 : Reverse-transcription PCR and Western blot analysis revealed that MMP-2, VEGF , p-JNK and p-p38 were up-regulated by the silencing of Smad4 , while the expression of MMP-9 and p-Erk1/2 was not affected by Smad4 silencing with or without TGF-ß1 stimulation
Lee et al., Cell Tissue Res 2012 (Glomerulonephritis, Membranous...) : Furthermore, activated TGF-ß/Smad signaling by podocytes may induce connective tissue growth factor and vascular endothelial growth factor overexpression, which could act as a paracrine effector mechanism on mesangial cells to stimulate mesangial matrix synthesis
Li et al., Arthritis Res Ther 2012 (Osteoarthritis) : Furthermore, miR-146a upregulation of VEGF is mediated by Smad4
Bai et al., Development 2013 (Truncus Arteriosus, Persistent...) : Our findings indicate that Smad directly binds to Vegfa chromatin and represses Vegfa transcriptional activity