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UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining

◀ Back to MED23

CDK19 — MED23

Pathways - manually collected, often from reviews:

  • Reactome Reaction: CDK19 → MED23 (direct_complex)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Lee et al., Mol Cell Biol 1999 : The Mediator complex of Saccharomyces cerevisiae is required for both general and regulated transcription of RNA polymerase II (PolII) and is composed of two stable subcomplexes ( Srb4 and Rgr1 subcomplexes )
Spåhr et al., J Biol Chem 2000 : This stimulation was species-specific, because S. pombe Mediator could not stimulate TFIIH purified from S. cerevisiae
Mittler et al., EMBO Rep 2001 : Novel critical role of a human Mediator complex for basal RNA polymerase II transcription
Wang et al., J Biol Chem 2002 : Mediator role of platelet derived growth factor and ERK
Wang et al., J Virol 2002 (Cell Transformation, Viral) : Much of the large E1A bound to Mediator in 293 cells is in a stable complex that includes RNA polymerase II, leading us to suggest that the interaction of E1A-CR3 with Mediator stabilizes the interaction of Mediator with the polymerase
Acevedo et al., Mol Cell Biol 2003 : We have used a biochemical approach, including an in vitro chromatin assembly and transcription system, to examine the functional role for Mediator in the transcriptional activity of estrogen receptor alpha (ERalpha) with chromatin templates, as well as functional interplay between Mediator and p300/CBP during ERalpha dependent transcription ... Using three different approaches to functionally inactivate Mediator ( immunoneutralization, immunodepletion, and inhibitory polypeptides ), we find that Mediator is required for maximal transcriptional activation by ligand activated ERalpha
Zakharova et al., J Biol Chem 2003 : Furthermore, in a system with purified proteins and naked DNA, STAT1alpha- and STAT1beta dependent transcription is stimulated by the TRAP/Mediator co-activator complex ... Furthermore, in a system with purified proteins and naked DNA, STAT1alpha- and STAT1beta dependent transcription is stimulated by the TRAP/Mediator co-activator complex
Guidi et al., J Biol Chem 2004 : Mediator , a global transcriptional co-activator, dramatically enhances the phosphorylation of the CTD of RNA pol II by holo-TFIIH in vitro ... Using purified proteins we have determined that the subunits of TFIIK are sufficient for Mediator to enhance Kin28 CTD kinase activity and that Mediator enhances phosphorylation of a glutathione S-transferase-CTD fusion protein, despite the absence of multiple Mediator and/or TFIIH interactions with polymerase ... Using purified proteins we have determined that the subunits of TFIIK are sufficient for Mediator to enhance Kin28 CTD kinase activity and that Mediator enhances phosphorylation of a glutathione S-transferase-CTD fusion protein, despite the absence of multiple Mediator and/or TFIIH interactions with polymerase
Sato et al., Mol Cell 2004 : The Mediator is a multiprotein transcriptional coactivator that is expressed ubiquitously in eukaryotes from yeast to mammals and is required for induction of RNA polymerase II (pol II) transcription by DNA binding transcription factors ... The Mediator is a multiprotein transcriptional coactivator that is expressed ubiquitously in eukaryotes from yeast to mammals and is required for induction of RNA polymerase II (pol II) transcription by DNA binding transcription factors
Wang et al., Genetics 2004 : The rgr1 and sin4 constitutive phenotype does not require either the MAL-activator or maltose permease, indicating that Mediator represses MAL basal expression ... The role of the Mediator in MAL gene regulation is discussed
Pavri et al., Mol Cell 2005 : Importantly, Mediator was inactive ( Cdk8+ ) under basal conditions but was activated ( Cdk8- ) upon induction
Malik et al., Trends Biochem Sci 2005 : Dynamic regulation of pol II transcription by the mammalian Mediator complex
Govind et al., Mol Cell Biol 2005 : We confirm the roles of Mediator and SAGA in TATA binding protein (TBP) recruitment and demonstrate that all four coactivators under study enhance Pol II recruitment or promoter clearance following TBP binding
Takagi et al., J Biol Chem 2006 : Taken together, these findings lead to the suggestion that Mediator is required for basal RNA polymerase II transcription in vivo
Kim et al., J Biol Chem 2006 : The beta-catenin transactivation domain bound directly to isolated MED12 and intact Mediator both in vitro and in vivo, and Mediator was recruited to Wnt-responsive genes in a beta-catenin dependent manner
Black et al., Mol Cell 2006 : Using purified proteins, we found that the Mediator regulates this assembly process by binding to p300 and TFIID
Zhou et al., Mol Cell Biol 2006 : We propose that activated Gli3 physically targets the MED12 interface within Mediator in order to functionally reverse Mediator dependent suppression of Shh target gene transcription
Liu et al., Mol Cell Biol 2008 : STAF65gamma is required for SPT3/STAGA interaction with core Mediator and for MYC recruitment of SPT3, TAF9, and core Mediator components to the TERT promoter but is dispensable for MYC recruitment of TRRAP, GCN5, and p300 and for acetylation of nucleosomes and loading of TFIID and RNA polymerase II on the promoter
Ge et al., Mol Cell Biol 2008 : These results indicate that there is a conditional requirement for MED1/TRAP220 and that a direct interaction between PPARgamma and Mediator through MED1/TRAP220 is not essential either for PPARgamma stimulated adipogenesis or for PPARgamma target gene expression in cultured fibroblasts ... As Mediator is apparently essential for PPARgamma transcriptional activity, our data indicate the presence of alternative mechanisms for Mediator recruitment, possibly through intermediate cofactors or other cofactors that are functionally redundant with MED1/TRAP220
Belakavadi et al., Mol Cell Biol 2008 : Here, we report that phosphorylation of MED1 by mitogen activated protein kinase-extracellular signal regulated kinase ( MAPK-ERK ) promotes its association with Mediator
Contreras-Levicoy et al., FEBS J 2008 : Activation of transcription by PC4 was dependent on the Mediator complex and TFIIA, but was independent of TATA binding protein associated factor
Tsutsui et al., Genes Cells 2008 : While the role of CDK8 has been studied extensively, little is known of the role of CDK11 in Mediator
Thiaville et al., Nucleic Acids Res 2008 : It is unclear whether Mediator complex in yeast is necessary for all RNA polymerase II (Pol II) transcription or if it is limited to genes activated by environmental stress
Carey et al., Cold Spring Harbor protocols 2010 : INTRODUCTION : The Mediator ( Med ) complex plays a key role in promoter-specific activation of transcription by RNA polymerase II (Pol II)
Kunin et al., PloS one 2010 : Mediator of DNA damage checkpoint 1 ( MDC1 ) contributes to high NaCl induced activation of the osmoprotective transcription factor TonEBP/OREBP
Xu et al., EMBO Rep 2011 (Alzheimer Disease) : Mediator , in a MED12 dependent manner, occupies only AICD bound promoter DNA, indicating that the AICD recruits Mediator to activate transcription
Lin et al., Genes Dev 2011 : Studies in depleted extracts showed that the Mediator coactivator complex, which controls PIC assembly, is also necessary for CHD1 recruitment
Ang et al., PLoS Biol 2012 : Furthermore, we have found that Mediator controls the galactose induced protein degradation of Gal80 , which places Mediator genetically upstream of the activator Gal4 ... Furthermore, we have found that Mediator controls the galactose induced protein degradation of Gal80, which places Mediator genetically upstream of the activator Gal4
Lewis et al., Clin Exp Allergy 2013 : Mediator release induced by SCF was accompanied by the up-regulation of the activation marker, CD63
Kim et al., J Biol Chem 2013 : Mediator recruitment to heat shock genes requires dual Hsf1 activation domains and mediator tail subunits Med15 and Med16 ... Mediator recruitment to heat shock genes requires dual Hsf1 activation domains and mediator tail subunits Med15 and Med16
Verger et al., Nucleic Acids Res 2013 : We further show that depletion of MED25 disrupts the association of ERM with the Mediator in vitro
Galbraith et al., Cell 2013 (Neoplasms) : HIF1A Employs CDK8-Mediator to Stimulate RNAPII Elongation in Response to Hypoxia ... HIF1A induces binding of CDK8-Mediator and the super elongation complex ( SEC ), containing AFF4 and CDK9, to alleviate RNAPII pausing
Šedý et al., J Immunol 2013 (Inflammation) : CD160 Activation by Herpesvirus Entry Mediator Augments Inflammatory Cytokine Production and Cytolytic Function by NK Cells
Newman et al., Endocrinology 1985 : Mediator generation was rapid, with a half-time of approximately 45 sec and was insulin dose dependent
Han et al., Mol Cell Biol 1999 : The multisubunit Mediator complex of Saccharomyces cerevisiae is required for most RNA polymerase II (Pol II) transcription