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C1ORF228 — IFNG

Text-mined interactions from Literome

Cowdery et al., J Immunol 1999 : In the presence of IFN-gamma , CpG DNA induces more p40 secretion than does LPS
Liu et al., Cytokine 1999 (Lupus Erythematosus, Systemic) : SAC stimulated IL-12 p35 and p40 mRNAs were significantly augmented by interferon gamma (IFN-gamma)
Ma et al., J Immunol 2000 : The major transcriptional factors identified to be involved in the regulation of IL-12 p40 gene expression by LPS and IFN-gamma , i.e., c-Rel, NF-kappaB p50 and p65, IFN regulatory factor-1, and ets-2, were not affected by TNF-alpha when examined by nuclear translocation and DNA binding
Rottenberg et al., J Immunol 2000 (Chlamydia Infections...) : In turn, IFN-gamma is necessary for the increased IL-12p40 mRNA accumulation that occurs in lungs during infection with C. pneumoniae, suggesting a positive feedback regulation between these two cytokines
Petro et al., Int Immunopharmacol 2002 : Both p70 and p40 are produced by macrophages in response to lipopolysaccharide (LPS), IFN-gamma and/or CD40 ligation
Baldwin et al., Vet Microbiol 2002 (Brucellosis...) : The hiatus of IFN-gamma production in BALB/c mice correlated with very high levels of total IL-12 and it was postulated that the lack of IFN-gamma was a consequence of p40 homodimer blocking activity
Bradford et al., J Biomed Sci 2002 : The regulation of macrophage IL-12 p40 secretion in response to stimulation with LPS and interferon-gamma (IFN-gamma) is dependent on the action of a nuclear transacting factor, interferon consensus sequence binding protein ( ICSBP ), a STAT1 dependent gene product
Stoffels et al., J Autoimmun 2004 (Necrosis) : In contrast, NOD macrophages failed to up-regulate IL1beta and IL12p40 in response to IFNgamma
Shimozato et al., Immunology 2006 (Colonic Neoplasms) : p40 also suppressed IFN-gamma production of antigen stimulated splenocytes and IL-23 mediated cytotoxic T-lymphocyte activities in the mice that rejected Colon 26 cells expressing IL-23
An et al., J Ethnopharmacol 2006 : However, GH increased IFN-gamma/LPS induced IL-12p40 production
Olleros et al., Immunology 2007 (Granuloma...) : Interleukin (IL)-12p40 , a subunit of IL-12p70 and IL-23, has previously been shown to inhibit IL-12p70 activity and interferon-gamma (IFN-gamma) production
Gómez-Laguna et al., J Comp Pathol 2010 (Porcine Reproductive and Respiratory Syndrome) : The results also suggest that expression of IFN-gamma is stimulated by IL-12p40 and TNF-alpha, but not by IFN-alpha
Yamauchi et al., International journal of biological sciences 2009 : AZM also reduced LPS/IFN-gamma induced IL-12p40 promoter activity
Cassatella et al., Eur J Immunol 1995 : Therefore, the combined effect of LPS and IFN-gamma induced sufficient expression of both p40 and p35 to attain production of the biologically active p70 heterodimer at physiologically relevant concentrations
Mattner et al., Eur J Immunol 1993 : IFN-gamma production by Th1 cells induced in a T cell receptor independent way by macrophages and IL-2 or macrophages and IL-12 was greatly reduced by IL-12p40 providing evidence for the endogenous synthesis of IL-12 in the Th1 cell, macrophage and IL-2 co-cultures
Aloisi et al., J Immunol 1997 : Combined stimulation with IFN-gamma/LPS enhances IL-12 p40 secretion and induces IL-12 p75 secretion by microglia
Poggi et al., Int Immunol 1997 : In addition, cross linking of p40 molecules strongly inhibited the CD94 induced tumor necrosis factor-alpha and IFN-gamma production
Yasuda et al., J Clin Invest 1998 (Diabetes Mellitus, Type 1) : Reverse transcription-PCR analysis revealed that local production of IL-12p40 led to the decrease of interferon-gamma and the augmentation of transforming growth factor-beta at the graft site