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INS — PDHX

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Nakai et al., Metabolism 1999 : Insulin activation of pyruvate dehydrogenase complex is enhanced by exercise training
Carlsen et al., Cell Signal 1999 (MAP Kinase Signaling System) : Insulin stimulated pyruvate dehydrogenase activity was abolished by phosphatidylinositol 3-kinase inhibitors
Caruso et al., J Biol Chem 2001 : In L6 skeletal muscle cells and immortalized hepatocytes, insulin induced a 2-fold increase in the activity of the pyruvate dehydrogenase (PDH) complex
Shashkin et al., Int J Exp Diabetes Res 2002 : These data demonstrate that fasting specifically decreases the muscle content of D-chiroinositol in human muscle and this may contribute to the finding that insulin mediated activation of pyruvate dehydrogenase is attenuated after short-term starvation
Stentz et al., Curr Drug Targets 2003 (Diabetes Mellitus, Type 2) : In activated T-lymphocytes, insulin stimulates glucose uptake, glucose oxidation, pyruvate flux and pyruvate dehydrogenase activity, amino acid transport, lipid metabolism and protein synthesis
Contreras et al., Nephron 1992 (Kidney Failure, Chronic...) : In chronic uremia, insulin activates receptor kinase but not pyruvate dehydrogenase
Gottschalk et al., Biochem Biophys Res Commun 1992 : Insulin-like growth factor 1 (IGF-1) had no detectable effect on pyruvate dehydrogenase (PDH) in NIH 3T3 cells that stably overexpressed normal human IGF-1 receptors
Curto et al., Int J Biochem 1992 (Diabetes Mellitus, Type 1...) : The insulin signal and its effects on the pyruvate dehydrogenase complex in circulating lymphocytes of obese children
Clot et al., J Clin Endocrinol Metab 1992 (Dwarfism) : Human peripheral mononuclear cells ( PMC ) were used to examine the effects of hGH and insulin on the activity of the pyruvate dehydrogenase (PDH) complex
Rutter et al., Biochem J 1992 : Regulation of pyruvate dehydrogenase by insulin and polyamines within electropermeabilized fat-cells and isolated mitochondria ... 1. Regulation of the mammalian pyruvate dehydrogenase (PDH) complex by insulin and polyamines has been examined by using electropermeabilized rat epididymal fat-cells and isolated mitochondria
Rutter et al., Biochem J 1991 : 1. The effects of the protein phosphatase inhibitors okadaic acid and microcystin LR on the regulation by insulin of pyruvate dehydrogenase and acetyl-CoA carboxylase have been studied in rat epididymal fat-pads and isolated cells ... It is concluded that the effects of okadaic acid are exerted through changes in metabolite concentrations rather than some direct action on the signalling pathway whereby insulin stimulates pyruvate dehydrogenase
Chokkalingam et al., J Clin Endocrinol Metab 2007 (Insulin Resistance) : Insulin stimulated CHO oxidation and muscle pyruvate dehydrogenase complex activity were blunted after the HF diet
Smirnov et al., Farmakol Toksikol 1976 (Diabetes Mellitus, Experimental) : [ Effect of insulin , adrenaline and cyclic adenosine monophosphate on the activity of transport adenosine triphosphatases and pyruvate dehydrogenase of the rat myocardium under normal conditions and in insular insufficiency ]
Gottschalk et al., J Biol Chem 1991 : The pathway mediating insulin 's effects on pyruvate dehydrogenase bypasses the insulin receptor tyrosine kinase ... The effect of insulin on pyruvate dehydrogenase activity was examined in two different cell types that over expressed either normal or defective human insulin receptors, RAT 1 embryonic fibroblasts and Chinese hamster ovary ( CHO ) cells ... Insulin stimulated pyruvate dehydrogenase activity in cells that expressed normal insulin receptors ( RAT 1 HIRc, and CHO-WT and CHO-T cells ), or receptors in which lysine 1018 in the ATP binding site of the tyrosine kinase domain was exchanged for alanine ( RAT 1 A/K1018 and CHO-mut cells )
Stephens et al., Exp Physiol 2010 : Basal and insulin stimulated pyruvate dehydrogenase complex activation, glycogen synthesis and metabolic gene expression in human skeletal muscle the day after a single bout of exercise
Mandarino et al., J Clin Endocrinol Metab 1990 (Diabetes Mellitus, Type 2...) : The present studies were undertaken to determine whether fasting hyperglycemia can compensate for decreased insulin stimulated glucose disposal, oxidation, and storage in noninsulin dependent diabetes mellitus ( NIDDM ) as well as to determine whether hyperglycemia normalizes insulin stimulated skeletal muscle glycogen synthase and pyruvate dehydrogenase (PDH) activities
Romero et al., Proc Natl Acad Sci U S A 1990 : These antibodies ( i ) block the in vitro effects of purified insulin mediators and (ii) block the insulin induced stimulation of pyruvate dehydrogenase in intact BC3H1 myocytes but not insulin stimulated glucose uptake, generation of diacylglycerol, or generation of insulin mediators
Macaulay et al., Biochem J 1990 (Diabetes Mellitus, Experimental) : Impairment in insulin stimulated breakdown of the molecule in adipocytes of streptozotocin-diabetic rats was found, consistent with the impaired insulin activation of pyruvate dehydrogenase and glucose utilization seen in this model
Burnol et al., Am J Physiol 1990 : During the euglycemic hyperinsulinemic clamp, insulin entirely activated pyruvate dehydrogenase in lactating rat mammary gland, whereas after 24 h of weaning it was unable to increase the proportion of the enzyme in the active form
Hutson et al., Prog Clin Biol Res 1979 (Diabetes Mellitus, Experimental...) : Regulation of pyruvate dehydrogenase by insulin action
Cheng et al., Arch Biochem Biophys 1990 : The effects of insulin and ATP on pyruvate dehydrogenase were glucose dependent whereas the effect of adenosine was glucose independent
Luttrell et al., Mol Pharmacol 1986 : Hexose independent activation of glycogen synthase and pyruvate dehydrogenase by insulin is dissociated in the mouse BC3H-1 cell line ... In contrast, both insulin and the tumor promoting phorbol ester, tetradecanoylyl phorbol acetate markedly increased mitochondrial pyruvate dehydrogenase activity in the absence of hexose
Mandarino et al., J Clin Invest 1987 : To determine whether activation by insulin of glycogen synthase ( GS ), phosphofructokinase ( PFK ), or pyruvate dehydrogenase (PDH) in skeletal muscle regulates intracellular glucose metabolism, subjects were studied basally and during euglycemic insulin infusions of 12, 30, and 240 mU/m2 X min. Glucose disposal, oxidative and nonoxidative glucose metabolism were determined
Cheng et al., J Biol Chem 1985 : Similarly, the stimulation of pyruvate dehydrogenase and glycogen synthase by insulin was also observed under the same conditions
Thomas et al., Biochem J 1986 : The close similarity of the effects of spermine and the changes in kinetic properties of pyruvate dehydrogenase phosphate phosphatase within mitochondria from insulin treated adipose tissue suggests that insulin may activate pyruvate dehydrogenase by increasing the concentration of spermine within the mitochondria
Thomas et al., Biochem J 1986 : Since effects of insulin on pyruvate dehydrogenase phosphatase activity are not evident in mitochondrial extracts, it is concluded that insulin may act by altering some high-Mr component which interacts with the pyruvate dehydrogenase system within intact or permeabilized mitochondria, but not when the mitochondrial membranes are disrupted
Wong et al., FEBS Lett 1987 : Adenosine and oxytocin reverse antagonism of cyclic AMP elevating agents to insulin activation of adipocyte pyruvate dehydrogenase ... The stimulatory effects of insulin , adenosine and oxytocin on adipocyte pyruvate dehydrogenase appear to be through ( a ) mechanism ( s ) which is ( are ) similar or related
Rinaudo et al., Int J Biochem 1988 (Diabetes Mellitus, Experimental) : Effects of insulin on pyruvate dehydrogenase in circulating lymphocytes from normal and diabetic rats
Clot et al., Metabolism 1988 : The effects of growth hormone and insulin on the activity of pyruvate dehydrogenase were examined in the rat, both in vivo and in isolated hepatocytes ... The effects of 100 nmol/L hGH and 100 nmol/L insulin on pyruvate dehydrogenase activity were not additive
Cheng et al., Arch Biochem Biophys 1987 : On the other hand, insulin stimulated pyruvate dehydrogenase activity remained elevated for at least 30 min. Isoproterenol ( 10 ( -8 ) M ) stimulated phosphorylase and inhibited pyruvate dehydrogenase through the activation of beta-adrenergic receptors
Standaert et al., Endocrinology 1987 : Insulin and 12-O-tetradecanoyl phorbol 13-acetate ( TPA ) each acutely stimulates hexose transport, amino acid uptake, and pyruvate dehydrogenase activity in the BC3H-1 myocyte in a nonadditive fashion, suggesting that the acute effects of insulin and TPA are mediated through a common mechanism of action
Buffington et al., Biochem Biophys Res Commun 1986 : Phytohemagglutinin ( PHA ) activated human T-lymphocytes : concomitant appearance of insulin binding, degradation and insulin mediated activation of pyruvate dehydrogenase (PDH) ... Binding and degradation of A14125I-Insulin as well as the effect of insulin on pyruvate dehydrogenase (PDH) activation were studied in non stimulated and phytohemagglutinin ( PHA ) -stimulated thymic derived lymphocytes ( T-lymphocytes ) of man under varying conditions of time, temperature, and cell concentration
Jarett et al., Endocrinology 1985 : Stimulation of pyruvate dehydrogenase activity in intact rat adipocytes by insulin mediator from rat skeletal muscle ... This study compared the effects of insulin and insulin mediator from skeletal muscle of control and insulin treated rats on intact adipocyte pyruvate dehydrogenase
Schadewaldt et al., Biochem J 1985 : The data provide evidence that in resting perfused rat skeletal muscle insulin primarily increased the activity of the pyruvate dehydrogenase complex
Rinaudo et al., Ital J Biochem 1985 (Diabetes Mellitus, Experimental) : Effect of insulin on the pyruvate dehydrogenase complex in the rat brain
Jarett et al., Science 1985 : Insulin and insulin mediator stimulated both pyruvate dehydrogenase and glycogen synthase activity of intact adipocytes
Paetzke-Brunner et al., Horm Metab Res 1979 : Activation of pyruvate dehydrogenase by insulin in isolated brown fat cells
Ohlen et al., Diabetologia 1978 (Diabetes Mellitus, Experimental) : The effect of insulin on pyruvate dehydrogenase interconversion in heart muscle of alloxan-diabetic rats
Denton et al., Biochem J 1984 : Persistence of the effect of insulin on pyruvate dehydrogenase activity in rat white and brown adipose tissue during the preparation and subsequent incubation of mitochondria ... No alterations were found, and it is suggested that inhibition of the kinase is not the principal means by which insulin activates pyruvate dehydrogenase ... It is pointed out that the persistence of the effect of insulin on pyruvate dehydrogenase in incubated mitochondria will facilitate the recognition of the mechanism of this action of the hormone
Farese et al., Diabetes 1984 : We studied certain metabolic requirements for insulin induced increases in phospholipids, and the relationship of phospholipid changes to the insulin induced activation of pyruvate dehydrogenase , in rat adipocytes and fat pads in vitro ... Effects of insulin on phospholipid metabolism and pyruvate dehydrogenase were found to require an exogenous carbohydrate source, and fructose was nearly as effective as glucose in this regard
Rinaudo et al., Boll Soc Ital Biol Sper 1983 (Diabetes Mellitus, Experimental) : [ Effect of insulin on brain pyruvate dehydrogenase in the rat
Rinaudo et al., Boll Soc Ital Biol Sper 1984 (Diabetes Mellitus, Experimental) : The effect of insulin and ATP on pyruvate dehydrogenase activity has been studied in a mixture of plasma membranes/mitochondria from normal and diabetic rat brain
Farese et al., J Biol Chem 1984 : Effects of insulin and protein synthesis inhibitors on phospholipid metabolism, diacylglycerol levels, and pyruvate dehydrogenase activity in BC3H-1 cultured myocytes
Buffington et al., Diabetes 1984 : Activation of pyruvate dehydrogenase complex by porcine and biosynthetic human insulin in cultured human fibroblasts
Wong et al., FEBS Lett 1984 : Effect of adenosine on insulin activation of rat adipocyte pyruvate dehydrogenase
Cheng et al., Mol Cell Biochem 1983 : The failure of lithium ion to thus mimic insulin actions on pyruvate dehydrogenase and on phosphorylase suggests that the action of lithium ion on glycogen synthase is quite specific and may be mediated by stimulating a phosphatase or by inhibiting a protein kinase acting specifically on glycogen synthase
Hutchinson et al., Br J Anaesth 1980 (Diabetes Mellitus, Experimental...) : The combination of starvation and halothane anaesthesia may impair mitochondrial accumulation of calcium which may be involved in the stimulation of pyruvate dehydrogenase by insulin
Kiechle et al., Diabetes 1980 : Isolation from rat adipocytes of a chemical mediator for insulin activation of pyruvate dehydrogenase
Imura et al., Horm Metab Res 1981 (Diabetes Mellitus, Experimental) : Short term regulation of mouse pyruvate dehydrogenase complex by insulin
Begum et al., Endocrinology 1982 : Basal and insulin stimulated epididymal fat pad pyruvate dehydrogenase (PDH) activities were decreased in fat diet adapted rats compared to those fed the glucose diet
Assimacopoulos-Jeannet et al., Biochim Biophys Acta 1982 : The effect of insulin on the activity of pyruvate dehydrogenase is studied in isolated hepatocytes from fed rats ... Insulin increases the ` initial ' activity of pyruvate dehydrogenase by 30 % without modifying the total activity of the enzyme
Vaag et al., Eur J Endocrinol 1994 : Insulin increased the activity of the active form of pyruvate dehydrogenase on the control day, but not during Intralipid infusion
Feldhoff et al., Metabolism 1993 (Diabetes Mellitus, Experimental) : Insulin induced activation of pyruvate dehydrogenase complex in skeletal muscle of diabetic rats
Sugden et al., J Mol Cell Cardiol 1997 : Molecular mechanisms underlying the long-term impact of dietary fat to increase cardiac pyruvate dehydrogenase kinase : regulation by insulin , cyclic AMP and pyruvate
Moule et al., Am J Cardiol 1997 : The short-term metabolic effects of insulin appear to involve at least 3 distinct signaling pathways : ( 1 ) those leading to increases in glucose transport and the activation of glycogen synthase, acetyl-CoA carboxylase, eukaryotic initiation factor-2B, and phosphodiesterase, which may involve phosphatidylinositol 3-kinase and protein kinase B ; ( 2 ) those leading to some of the effects of insulin on protein synthesis ( formation of eukaryotic initiation factor-4F complex, S6 phosphorylation, and activation of eukaryotic elongation factor-2 ), which may involve phosphatidylinositol 3-kinase and p70 S6 kinase ; and finally, ( 3 ) that leading to the activation of pyruvate dehydrogenase , which is unique in apparently not requiring activation of phosphatidylinositol 3-kinase
Curto et al., Int J Biochem Cell Biol 1997 : G proteins and regulation of pyruvate dehydrogenase activity by insulin in human circulating lymphocytes
Rao et al., J Thorac Cardiovasc Surg 1998 (Myocardial Reperfusion Injury) : Insulin increased the pyruvate dehydrogenase activity by 31 % in cardiomyocytes and reduced extracellular lactate production by 40 %